Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Journal article, 2020
Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.
Author
Antonio Molinaro
Wallenberg Lab.
Pierre Bel Lassen
Pierre and Marie Curie University (UPMC)
Marcus Henricsson
Wallenberg Lab.
Hao Wu
Wallenberg Lab.
Solia Adriouch
Pierre and Marie Curie University (UPMC)
Eugeni Belda
Pierre and Marie Curie University (UPMC)
Rima Chakaroun
Leipzig University
Trine Nielsen
University of Copenhagen
Per Olof Bergh
Wallenberg Lab.
Christine Rouault
Pierre and Marie Curie University (UPMC)
Sébastien André
Pierre and Marie Curie University (UPMC)
Florian Marquet
Pierre and Marie Curie University (UPMC)
Fabrizio Andreelli
Pierre and Marie Curie University (UPMC)
Joe-Elie Salem
Assistance publique – Hôpitaux de Paris (AP-HP)
Karen Assmann
Pierre and Marie Curie University (UPMC)
Jean-Phillippe Bastard
Assistance publique – Hôpitaux de Paris (AP-HP)
Sofia K. Forslund
The Max Delbrück Center for Molecular Medicine
Emmanuelle Le Chatelier
University Paris-Saclay
Gwen Falony
KU Leuven
Nicolas Pons
University Paris-Saclay
Edi Prifti
Assistance publique – Hôpitaux de Paris (AP-HP)
Benoit Quinquis
University Paris-Saclay
Hugo Roume
University Paris-Saclay
Sara Vieira-Silva
KU Leuven
Tue H. Hansen
University of Copenhagen
Helle K. Pedersen
University of Copenhagen
Christian Lewinter
University of Copenhagen
Nadja B. Søndertoft
University of Copenhagen
Renato Alves
European Molecular Biology Laboratory
Chloe Amouyal
Pierre and Marie Curie University (UPMC)
Ehm Astrid Andersson Galijatovic
University of Copenhagen
Olivier Barthelemy
Assistance publique – Hôpitaux de Paris (AP-HP)
Jean-Paul Batisse
Assistance publique – Hôpitaux de Paris (AP-HP)
Magalie Berland
University Paris-Saclay
Randa Bittar
Assistance publique – Hôpitaux de Paris (AP-HP)
Hervé Blottière
University Paris-Saclay
Frederic Bosquet
Assistance publique – Hôpitaux de Paris (AP-HP)
Rachid Boubrit
Assistance publique – Hôpitaux de Paris (AP-HP)
Olivier Bourron
Assistance publique – Hôpitaux de Paris (AP-HP)
Mickael Camus
University Paris-Saclay
Dominique Cassuto
Assistance publique – Hôpitaux de Paris (AP-HP)
J. Chilloux
Imperial College London
Cecile Ciangura
Assistance publique – Hôpitaux de Paris (AP-HP)
Luis P. Coelho
European Molecular Biology Laboratory
Jean-Philippe Collet
Assistance publique – Hôpitaux de Paris (AP-HP)
Maria-Carlota Dao
Pierre and Marie Curie University (UPMC)
Morad Djebbar
Assistance publique – Hôpitaux de Paris (AP-HP)
Angélique Doré
University Paris-Saclay
Line Engelbrechtsen
Pierre and Marie Curie University (UPMC)
Soraya Fellahi
Assistance publique – Hôpitaux de Paris (AP-HP)
Leopold Fezeu
University of Paris North
Sebastien Fromentin
University Paris-Saclay
Philippe Giral
Assistance publique – Hôpitaux de Paris (AP-HP)
Jens P. Gøtze
University of Copenhagen
Agnes Hartemann
Assistance publique – Hôpitaux de Paris (AP-HP)
Jens Juul Holst
University of Copenhagen
Serge Hercberg
University of Paris North
Gerard Helft
Assistance publique – Hôpitaux de Paris (AP-HP)
Malene Hornbak
University of Copenhagen
Jean-Sébastien Hulot
Pierre and Marie Curie University (UPMC)
Richard Isnard
Assistance publique – Hôpitaux de Paris (AP-HP)
Sophie Jaqueminet
University Paris-Saclay
Niklas Rye Jørgensen
University of Copenhagen
Hanna Julienne
University Paris-Saclay
Johanne Justesen
University of Copenhagen
Judith Kammer
Leipzig University
Nikolaj Krarup
University of Copenhagen
Mathieu Kerneis
Assistance publique – Hôpitaux de Paris (AP-HP)
Jean Khemis
Assistance publique – Hôpitaux de Paris (AP-HP)
Nadja Buus Kristensen
University of Copenhagen
Michael Kuhn
European Molecular Biology Laboratory
Véronique Lejard
University Paris-Saclay
Florence Levenez
University Paris-Saclay
Lea Lucas-Martini
Assistance publique – Hôpitaux de Paris (AP-HP)
Robin Massey
University Paris-Saclay
Nicolas Maziers
University Paris-Saclay
Jonathan Medina-Stamminger
Assistance publique – Hôpitaux de Paris (AP-HP)
Gilles Montalescot
Assistance publique – Hôpitaux de Paris (AP-HP)
Sandrine Moutel
Assistance publique – Hôpitaux de Paris (AP-HP)
Laetitia Pasero Le Pavin
University Paris-Saclay
Christine Poitou
Pierre and Marie Curie University (UPMC)
Francoise Pousset
Assistance publique – Hôpitaux de Paris (AP-HP)
Laurence Pouzoulet
Assistance publique – Hôpitaux de Paris (AP-HP)
Sebastian Schmidt
European Molecular Biology Laboratory
Lucas Moitinho-Silva
European Molecular Biology Laboratory
Johanne Silvain
Assistance publique – Hôpitaux de Paris (AP-HP)
Nataliya Sokolovska
Pierre and Marie Curie University (UPMC)
Sothea Touch
Pierre and Marie Curie University (UPMC)
Mathilde Svendstrup
University of Copenhagen
Timothy Swartz
Pierre and Marie Curie University (UPMC)
Thierry Vanduyvenboden
University Paris-Saclay
Camille Vatier
Assistance publique – Hôpitaux de Paris (AP-HP)
Stefanie Walther
Leipzig University
Lars Køber
University of Copenhagen
H. Vestergaard
University of Copenhagen
Torben Hansen
University of Copenhagen
Jean-Daniel Zucker
UMMISCO
Pilar Galan
University of Paris North
Marc-Emmanuel Dumas
Imperial College London
Jeroen Raes
University Paris-Saclay
Jean-Michel Oppert
Assistance publique – Hôpitaux de Paris (AP-HP)
Ivica Letunic
Biobyte Solutions
Jens B Nielsen
Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology
Peer Bork
European Molecular Biology Laboratory
Stanislav Dusko Ehrlich
University Paris-Saclay
M. Stumvoll
Leipzig University
O. B. Pedersen
University of Copenhagen
Judith Aron-Wisneswky
Pierre and Marie Curie University (UPMC)
K. Clement
Pierre and Marie Curie University (UPMC)
Fredrik Bäckhed
Wallenberg Lab.
Nature Communications
2041-1723 (ISSN) 20411723 (eISSN)
Vol. 11 1 5881Subject Categories
Endocrinology and Diabetes
Other Clinical Medicine
Nutrition and Dietetics
DOI
10.1038/s41467-020-19589-w
PubMed
33208748