Imidazole propionate is increased in diabetes and associated with dietary patterns and altered microbial ecology
Journal article, 2020

Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism. Here, we show that subjects with prediabetes and diabetes in the MetaCardis cohort from three European countries have elevated serum imidazole propionate levels. Furthermore, imidazole propionate levels were increased in subjects with low bacterial gene richness and Bacteroides 2 enterotype, which have previously been associated with obesity. The Bacteroides 2 enterotype was also associated with increased abundance of the genes involved in imidazole propionate biosynthesis from dietary histidine. Since patients and controls did not differ in their histidine dietary intake, the elevated levels of imidazole propionate in type 2 diabetes likely reflects altered microbial metabolism of histidine, rather than histidine intake per se. Thus the microbiota may contribute to type 2 diabetes by generating imidazole propionate that can modulate host inflammation and metabolism.

Author

Antonio Molinaro

Wallenberg Lab.

Pierre Bel Lassen

Pierre and Marie Curie University (UPMC)

Marcus Henricsson

Wallenberg Lab.

Hao Wu

Wallenberg Lab.

Solia Adriouch

Pierre and Marie Curie University (UPMC)

Eugeni Belda

Pierre and Marie Curie University (UPMC)

Rima Chakaroun

Leipzig University

Trine Nielsen

University of Copenhagen

Per Olof Bergh

Wallenberg Lab.

Christine Rouault

Pierre and Marie Curie University (UPMC)

Sébastien André

Pierre and Marie Curie University (UPMC)

Florian Marquet

Pierre and Marie Curie University (UPMC)

Fabrizio Andreelli

Pierre and Marie Curie University (UPMC)

Joe-Elie Salem

Assistance publique – Hôpitaux de Paris (AP-HP)

Karen Assmann

Pierre and Marie Curie University (UPMC)

Jean-Phillippe Bastard

Assistance publique – Hôpitaux de Paris (AP-HP)

Sofia K. Forslund

Max Delbruck Center for Molecular Medicine

Emmanuelle Le Chatelier

University Paris-Saclay

Gwen Falony

KU Leuven

Nicolas Pons

University Paris-Saclay

Edi Prifti

Assistance publique – Hôpitaux de Paris (AP-HP)

Benoit Quinquis

University Paris-Saclay

Hugo Roume

University Paris-Saclay

Sara Vieira-Silva

KU Leuven

Tue H. Hansen

University of Copenhagen

Helle K. Pedersen

University of Copenhagen

Christian Lewinter

University of Copenhagen

Nadja B. Søndertoft

University of Copenhagen

Renato Alves

European Molecular Biology Laboratory

Chloe Amouyal

Pierre and Marie Curie University (UPMC)

Ehm Astrid Andersson Galijatovic

University of Copenhagen

Olivier Barthelemy

Assistance publique – Hôpitaux de Paris (AP-HP)

Jean-Paul Batisse

Assistance publique – Hôpitaux de Paris (AP-HP)

Magalie Berland

University Paris-Saclay

Randa Bittar

Assistance publique – Hôpitaux de Paris (AP-HP)

Hervé Blottière

University Paris-Saclay

Frederic Bosquet

Assistance publique – Hôpitaux de Paris (AP-HP)

Rachid Boubrit

Assistance publique – Hôpitaux de Paris (AP-HP)

Olivier Bourron

Assistance publique – Hôpitaux de Paris (AP-HP)

Mickael Camus

University Paris-Saclay

Dominique Cassuto

Assistance publique – Hôpitaux de Paris (AP-HP)

J. Chilloux

Imperial College London

Cecile Ciangura

Assistance publique – Hôpitaux de Paris (AP-HP)

Luis P. Coelho

European Molecular Biology Laboratory

Jean-Philippe Collet

Assistance publique – Hôpitaux de Paris (AP-HP)

Maria-Carlota Dao

Pierre and Marie Curie University (UPMC)

Morad Djebbar

Assistance publique – Hôpitaux de Paris (AP-HP)

Angélique Doré

University Paris-Saclay

Line Engelbrechtsen

Pierre and Marie Curie University (UPMC)

Soraya Fellahi

Assistance publique – Hôpitaux de Paris (AP-HP)

Leopold Fezeu

University of Paris North

Sebastien Fromentin

University Paris-Saclay

Philippe Giral

Assistance publique – Hôpitaux de Paris (AP-HP)

Jens P. Gøtze

University of Copenhagen

Agnes Hartemann

Assistance publique – Hôpitaux de Paris (AP-HP)

Jens Juul Holst

University of Copenhagen

Serge Hercberg

University of Paris North

Gerard Helft

Assistance publique – Hôpitaux de Paris (AP-HP)

Malene Hornbak

University of Copenhagen

Jean-Sébastien Hulot

Pierre and Marie Curie University (UPMC)

Richard Isnard

Assistance publique – Hôpitaux de Paris (AP-HP)

Sophie Jaqueminet

University Paris-Saclay

Niklas Rye Jørgensen

University of Copenhagen

Hanna Julienne

University Paris-Saclay

Johanne Justesen

University of Copenhagen

Judith Kammer

Leipzig University

Nikolaj Krarup

University of Copenhagen

Mathieu Kerneis

Assistance publique – Hôpitaux de Paris (AP-HP)

Jean Khemis

Assistance publique – Hôpitaux de Paris (AP-HP)

Nadja Buus Kristensen

University of Copenhagen

Michael Kuhn

European Molecular Biology Laboratory

Véronique Lejard

University Paris-Saclay

Florence Levenez

University Paris-Saclay

Lea Lucas-Martini

Assistance publique – Hôpitaux de Paris (AP-HP)

Robin Massey

University Paris-Saclay

Nicolas Maziers

University Paris-Saclay

Jonathan Medina-Stamminger

Assistance publique – Hôpitaux de Paris (AP-HP)

Gilles Montalescot

Assistance publique – Hôpitaux de Paris (AP-HP)

Sandrine Moutel

Assistance publique – Hôpitaux de Paris (AP-HP)

Laetitia Pasero Le Pavin

University Paris-Saclay

Christine Poitou

Pierre and Marie Curie University (UPMC)

Francoise Pousset

Assistance publique – Hôpitaux de Paris (AP-HP)

Laurence Pouzoulet

Assistance publique – Hôpitaux de Paris (AP-HP)

Sebastian Schmidt

European Molecular Biology Laboratory

Lucas Moitinho-Silva

European Molecular Biology Laboratory

Johanne Silvain

Assistance publique – Hôpitaux de Paris (AP-HP)

Nataliya Sokolovska

Pierre and Marie Curie University (UPMC)

Sothea Touch

Pierre and Marie Curie University (UPMC)

Mathilde Svendstrup

University of Copenhagen

Timothy Swartz

Pierre and Marie Curie University (UPMC)

Thierry Vanduyvenboden

University Paris-Saclay

Camille Vatier

Assistance publique – Hôpitaux de Paris (AP-HP)

Stefanie Walther

Leipzig University

Lars Køber

University of Copenhagen

H. Vestergaard

University of Copenhagen

Torben Hansen

University of Copenhagen

Jean-Daniel Zucker

UMMISCO

Pilar Galan

University of Paris North

Marc-Emmanuel Dumas

Imperial College London

Jeroen Raes

University Paris-Saclay

Jean-Michel Oppert

Assistance publique – Hôpitaux de Paris (AP-HP)

Ivica Letunic

Biobyte Solutions

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Peer Bork

European Molecular Biology Laboratory

Stanislav Dusko Ehrlich

University Paris-Saclay

M. Stumvoll

Leipzig University

O. B. Pedersen

University of Copenhagen

Judith Aron-Wisneswky

Pierre and Marie Curie University (UPMC)

K. Clement

Pierre and Marie Curie University (UPMC)

Fredrik Bäckhed

Wallenberg Lab.

Nature Communications

2041-1723 (ISSN)

Vol. 11 1 5881

Subject Categories

Endocrinology and Diabetes

Other Clinical Medicine

Nutrition and Dietetics

DOI

10.1038/s41467-020-19589-w

PubMed

33208748

More information

Latest update

12/2/2020