Modifying yeast tolerance to inhibitory conditions of ethanol production processes
Review article, 2015

Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory conditions are ideal for cost-competitive ethanol production from lignocellulose. A major drawback to directly design S. cerevisiae tolerance to inhibitory conditions of lignocellulosic ethanol production processes is the lack of knowledge about basic aspects of its cellular signaling network in response to stress. Here, we highlight the inhibitory conditions found in ethanol production processes, the targeted cellular functions, the key contributions of integrated -omics analysis to reveal cellular stress responses according to these inhibitors, and current status on design-based engineering of tolerant and efficient S. cerevisiae strains for ethanol production from lignocellulose.

ethanol production process

integrated-omics analysis

stress tolerance

cellular stress response

inhibitory environment

design-based engineering



Luis Caspeta-Guadarrama

Universidad Autonoma del Estado de Morelos

Tania Castillo

Universidad Autonoma del Estado de Morelos

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Novo Nordisk Foundation Center for Biosustainability

Frontiers in bioengineering and biotechnology

Vol. 3 Nov 184-

Subject Categories

Industrial Biotechnology

Areas of Advance


Life Science Engineering (2010-2018)





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