Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
Journal article, 2020

Microbiome community typing analyses have recently identified the Bacteroides2 (Bact2) enterotype, an intestinal microbiota configuration that is associated with systemic inflammation and has a high prevalence in loose stools in humans1,2. Bact2 is characterized by a high proportion of Bacteroides, a low proportion of Faecalibacterium and low microbial cell densities1,2, and its prevalence varies from 13% in a general population cohort to as high as 78% in patients with inflammatory bowel disease2. Reported changes in stool consistency3 and inflammation status4 during the progression towards obesity and metabolic comorbidities led us to propose that these developments might similarly correlate with an increased prevalence of the potentially dysbiotic Bact2 enterotype. Here, by exploring obesity-associated microbiota alterations in the quantitative faecal metagenomes of the cross-sectional MetaCardis Body Mass Index Spectrum cohort (n = 888), we identify statin therapy as a key covariate of microbiome diversification. By focusing on a subcohort of participants that are not medicated with statins, we find that the prevalence of Bact2 correlates with body mass index, increasing from 3.90% in lean or overweight participants to 17.73% in obese participants. Systemic inflammation levels in Bact2-enterotyped individuals are higher than predicted on the basis of their obesity status, indicative of Bact2 as a dysbiotic microbiome constellation. We also observe that obesity-associated microbiota dysbiosis is negatively associated with statin treatment, resulting in a lower Bact2 prevalence of 5.88% in statin-medicated obese participants. This finding is validated in both the accompanying MetaCardis cardiovascular disease dataset (n = 282) and the independent Flemish Gut Flora Project population cohort (n = 2,345). The potential benefits of statins in this context will require further evaluation in a prospective clinical trial to ascertain whether the effect is reproducible in a randomized population and before considering their application as microbiota-modulating therapeutics.

Author

Sara Vieira-Silva

KU Leuven

Gwen Falony

KU Leuven

Eugeni Belda

Pierre and Marie Curie University (UPMC)

Trine Nielsen

University of Copenhagen

Judith Aron-Wisnewsky

Pierre and Marie Curie University (UPMC)

Rima Chakaroun

Leipzig University

Sofia K. Forslund

Max Delbruck Center for Molecular Medicine

Karen Assmann

Pierre and Marie Curie University (UPMC)

Mireia Vallès-Colomer

KU Leuven

Thi Thuy Duyen Nguyen

KU Leuven

Sebastian Proost

KU Leuven

Edi Prifti

Pierre and Marie Curie University (UPMC)

Valentina Tremaroli

Wallenberg Lab.

Nicolas Pons

University Paris-Saclay

Emmanuelle Le Chatelier

University Paris-Saclay

Fabrizio Andreelli

Pierre and Marie Curie University (UPMC)

Jean-Phillippe Bastard

Pitie-Salpêtrière Hospital

Luis P. Coelho

European Molecular Biology Laboratory

Nathalie Galleron

University Paris-Saclay

Tue H. Hansen

University of Copenhagen

Jean-Sébastien Hulot

Hopital Pitie Salpetriere

Christian Lewinter

University of Copenhagen

Helle K. Pedersen

University of Copenhagen

Benoit Quinquis

University Paris-Saclay

Christine Rouault

Pierre and Marie Curie University (UPMC)

Hugo Roume

University Paris-Saclay

Joe-Elie Salem

Hopital Pitie Salpetriere

Nadja B. Søndertoft

University of Copenhagen

Sothea Touch

Pierre and Marie Curie University (UPMC)

Renato Alves

European Molecular Biology Laboratory

Chloe Amouyal

Pierre and Marie Curie University (UPMC)

Ehm Astrid Andersson Galijatovic

University of Copenhagen

Olivier Barthelemy

Pitie-Salpêtrière Hospital

Jean-Paul Batisse

Pitie-Salpêtrière Hospital

Magalie Berland

University Paris-Saclay

Randa Bittar

Pitie-Salpêtrière Hospital

Hervé Blottière

University Paris-Saclay

Frederic Bosquet

Pitie-Salpêtrière Hospital

Rachid Boubrit

Pitie-Salpêtrière Hospital

Olivier Bourron

Pitie-Salpêtrière Hospital

Mickael Camus

University Paris-Saclay

Dominique Cassuto

Pitie-Salpêtrière Hospital

Cecile Ciangura

Pitie-Salpêtrière Hospital

Jean-Philippe Collet

Pitie-Salpêtrière Hospital

Maria-Carlota Dao

Pierre and Marie Curie University (UPMC)

Jean Debedat

Pierre and Marie Curie University (UPMC)

Morad Djebbar

Pitie-Salpêtrière Hospital

Angélique Doré

University Paris-Saclay

Line Engelbrechtsen

University of Copenhagen

Soraya Fellahi

Pitie-Salpêtrière Hospital

Sebastien Fromentin

University Paris-Saclay

Philippe Giral

Pitie-Salpêtrière Hospital

Marianne Graine

Integromics Unit

Agnes Hartemann

Pitie-Salpêtrière Hospital

Bolette Hartmann

University of Copenhagen

Gerard Helft

Pitie-Salpêtrière Hospital

Serge Hercberg

U1153 INSERM

Malene Hornbak

University of Copenhagen

Richard Isnard

Pitie-Salpêtrière Hospital

Sophie Jaqueminet

Pitie-Salpêtrière Hospital

Niklas Rye Jørgensen

University of Copenhagen

Hanna Julienne

University Paris-Saclay

Johanne Justesen

University of Copenhagen

Judith Kammer

Leipzig University

Mathieu Kerneis

Pitie-Salpêtrière Hospital

Jean Khemis

Pitie-Salpêtrière Hospital

Nikolaj Krarup

University of Copenhagen

Michael Kuhn

European Molecular Biology Laboratory

Aurélie Lampuré

Pierre and Marie Curie University (UPMC)

Véronique Lejard

University Paris-Saclay

Florence Levenez

University Paris-Saclay

Lea Lucas-Martini

Pitie-Salpêtrière Hospital

Robin Massey

University Paris-Saclay

Nicolas Maziers

University Paris-Saclay

Jonathan Medina-Stamminger

Pitie-Salpêtrière Hospital

Lucas Moitinho-Silva

European Molecular Biology Laboratory

Gilles Montalescot

Pitie-Salpêtrière Hospital

Sandrine Moutel

Pitie-Salpêtrière Hospital

Laetitia Pasero Le Pavin

University Paris-Saclay

Christine Poitou-Bernert

Pierre and Marie Curie University (UPMC)

Francoise Pousset

Pitie-Salpêtrière Hospital

Laurence Pouzoulet

Pitie-Salpêtrière Hospital

Sebastian Schmidt

European Molecular Biology Laboratory

Johanne Silvain

Pitie-Salpêtrière Hospital

Mathilde Svendstrup

University of Copenhagen

Timothy Swartz

Pierre and Marie Curie University (UPMC)

Thierry Vanduyvenboden

University Paris-Saclay

Camille Vatier

Pitie-Salpêtrière Hospital

Eric Verger

Pierre and Marie Curie University (UPMC)

Stefanie Walther

Leipzig University

Marc-Emmanuel Dumas

Imperial College London

Stanislav Dusko Ehrlich

University Paris-Saclay

Pilar Galan

U1153 INSERM

Jens P. Gøtze

University of Copenhagen

Torben Hansen

University of Copenhagen

Jens Juul Holst

University of Copenhagen

Lars Køber

University of Copenhagen

Ivica Letunic

Biobyte Solutions

Jens B Nielsen

Chalmers, Biology and Biological Engineering, Systems and Synthetic Biology

Jean-Michel Oppert

Pitie-Salpêtrière Hospital

M. Stumvoll

Leipzig University

H. Vestergaard

University of Copenhagen

Jean-Daniel Zucker

Pierre and Marie Curie University (UPMC)

Peer Bork

European Molecular Biology Laboratory

O. B. Pedersen

University of Copenhagen

Fredrik Bäckhed

University of Copenhagen

K. Clement

Pierre and Marie Curie University (UPMC)

Jeroen Raes

KU Leuven

Nature

0028-0836 (ISSN) 1476-4687 (eISSN)

Vol. 581 7808 310-315

Subject Categories

Bioinformatics and Systems Biology

DOI

10.1038/s41586-020-2269-x

PubMed

32433607

More information

Latest update

8/24/2020