Systems biology: Developments and applications

Book chapter, 2014

© Springer-Verlag Berlin Heidelberg 2014. All rights are reserved. Systems biology relies on systems theory concepts and is applicable to both fundamental studies of cellular biology as well as applied research such as metabolic engineering. In this chapter, we map the context of systems biology developments and highlight its contribution in understanding the yeast carbon metabolism. Systems biology not only contributes towards the global overview of metabolism but also in combination with an integrative analysis approach facilitates the elucidation of molecular mechanisms. In particular we discuss the role of systems biology in unraveling the molecular details concerning glucose and galactose metabolism. In conclusion, this chapter provides an overview of the progress and impact of systems biology in carbon metabolism.