Integrated DEsign and AnaLysis of small population group trials (IDEAL)

There exist more than 7000 rare diseases worldwide and the European Society of Paediatric Oncology stated that 75% of rare diseases affect children and 30% of rare disease patients die before the age of five. Usual statistical methods for proving efficacy and safety of therapies fail to provide cost-efficient and reliable results in small populations. There is a pressing need to integrate a broad range of innovative methodologies improving clinical trials in the setting of small sample population groups (SPG). The objective of this research is to produce methods of general applicability irrespective of indication by Integrated DEsign and AnaLysis of clinical trials in SPG (IDEAL) through a multidisciplinary closely collaborating consortium of researchers from European universities, research institutes and industry. The consortium will work in 10 WPs, focussed on assessment of randomization procedures, extrapolating dose-response information, investigation of adaptive designs, optimal designs in mixed models, pharmacogenetic designs, simulation of clinical trials, genetic factors influencing the response, decision analysis and biomarker surrogate endpoints as well as WPs on project management and dissemination of results. Relevant stakeholder concerns (patient needs, regulatory issues, reimbursement, clinical feasibility) will be monitored by a Clinical Scientific Advisory Board. Because of its integrative structure, this research program extends previous approaches, which focus on a certain methodology only. In its totality, the WPs constitute a logically coherent set of methodologies that is of sufficient breadth to tackle these important, multidisciplinary challenges. By combining, enhancing and developing different statistical methodologies and assessment methods, this research program will impact the scientific discussion in promoting efficient statistical methodology for clinical trials in SPG, also in view of existing regulatory guidance in the EU.


Carl-Fredrik Burman (contact)

Gästforskare vid Chalmers, Mathematical Sciences, Applied Mathematics and Statistics


Centre De Recherche Public De La Sante

Luxembourg, Luxemburg

Medizinische Universitaet Wien

Wien, Austria

Politechnika Wroclawska

Wroclaw, Poland

Ruhr-Universität Bochum

Bochum, Germany

Universitaetsklinikum Aachen

Aachen, Germany

Universiteit Hasselt

Hasselt, Belgium

Uppsala University

Uppsala, Sweden


European Commission (FP7)

Funding Chalmers participation during 2013–2016 with 3,095,238.00 SEK

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