Gastrointestinala virus och nya effektiva orala vacciner

Research Project, 2015 – 2018

Noro- and rotavirus are two highly contagious agents that cause severe outbreaks of gastroenteric disease. They establish infection through binding to molecules in the lipid membrane of the host cell. Together these viruses are responsible for an annual mortality rate of > 1 million children and millions of cases of gastroenteritis worldwide. Given that a majority of pathogens gain access to the host via mucosal membranes a rational approach to preventing disease is through the development of mucosal vaccines. No vaccine is available against norovirus infection, and live attenuated mucosal rotavirus vaccines are expensive and less effective in developing countries. Therefore, the objective of the current proposal is to acquire information about the precise molecular interactions between virus and host cells and based on this information we will construct effective subcomponent mucosal vaccines for preventing infections. Our unique approach is to generate a library of IgA Mabs following oral immunization with virus-like particles (VLP). These IgA Mabs will then be used as a tool to screen viral strains for broadly protective and conserved epitopes, identified through analyzing antibody-blocking of carbohydrate-binding. A completely novel design of a mucosal vaccine will be developed by combining our patented CTA1-DD adjuvant with lipid-nanoparticles. It will have significant academic and commercial impact and pioneer development of the next generation of mucosal vaccines.

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