Oscillatory kinetics of gene expression: Protein conversion and slow mRNA transport
Journal article, 2009

The negative feedback between mRNA and regulatory-protein production may result in oscillations in the kinetics of gene expression if the mRNA-protein interplay includes protein conversion. Using a mean-field kinetic model, we show that such oscillations can be amplified due to limitations of the mRNA transport between the nucleus and cytoplasm. This effect may be dramatic for the mRNA population in the nucleus.


Vladimir Zhdanov

Chalmers, Applied Physics, Chemical Physics

Journal of Experimental and Theoretical Physics

1063-7761 (ISSN) 1090-6509 (eISSN)

Vol. 108 6 1050-1053

Subject Categories

Atom and Molecular Physics and Optics



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