Towards an electrowetting-based digital microfluidic platform for magnetic immunoassays
Journal article, 2009

We demonstrate ElectroWetting-On-Dielectric (EWOD) transport and SQUID gradiometer detection of magnetic nanoparticles (MNPs) suspended in a 2 mu l de-ionized water droplet. This proof-of-concept methodology constitutes the first development step towards a highly sensitive magnetic immunoassay platform with SQUID readout and droplet-based sample handling. Magnetic AC-susceptibility measurements were performed on MNPs with a hydrodynamic diameter of 100 nm using a high-Tc dc Superconducting Quantum Interference Device (SQUID) gradiometer as detector. We observed that the signal amplitude per unit volume is 2.5 times higher for a 2 ml sample droplet compared to a 30 ml sample volume.

Author

Vincent Schaller

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Anke Sanz-Velasco

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Alexei Kalaboukhov

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Justin Schneiderman

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Fredrik Öisjöen

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Aldo Jesorka

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Andrea Prieto Astalan

Imego AB - The Institute of Micro and Nanotechnology

Anatol Krozer

Imego AB - The Institute of Micro and Nanotechnology

Cristina Rusu

Imego AB - The Institute of Micro and Nanotechnology

Peter Enoksson

Chalmers, Applied Physics, Electronics Material and Systems Laboratory

Dag Winkler

Chalmers, Microtechnology and Nanoscience (MC2), Quantum Device Physics

Lab on a Chip - Miniaturisation for Chemistry and Biology

1473-0197 (ISSN) 1473-0189 (eISSN)

Vol. 9 23 3433-3436

Areas of Advance

Nanoscience and Nanotechnology (2010-2017)

Production

Life Science Engineering (2010-2018)

Subject Categories

Medical Laboratory and Measurements Technologies

Other Materials Engineering

Fluid Mechanics and Acoustics

Condensed Matter Physics

DOI

10.1039/b912646e

More information

Created

10/7/2017