Transition-Metal-Catalyzed Propargylic Substitution
Journal article, 2009
(Chemical Equation Presented) Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
acetates
alkylation
transition metals
propargylic
amination
nucleophilic substitution
asymmetric catalysis
complexes
alkynes
amines
enoxysilanes
alcohols
esters
nucleophilic-substitution
substitution
acetone
Author
N. Ljungdahl
Chalmers
Nina Kann
Chalmers, Chemical and Biological Engineering, Organic Chemistry
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 48 4 642-644Subject Categories
Physical Chemistry
Chemical Sciences
DOI
10.1002/anie.200804114