Transition-Metal-Catalyzed Propargylic Substitution
Artikel i vetenskaplig tidskrift, 2009

(Chemical Equation Presented) Keen for a share in the glory: Until recently, the title reaction stood in the shadows, its famous sister, catalytic allylic substitution, in the limelight. Catalytic propargylic substitution has now emerged as an efficient transformation that can be catalyzed by a variety of transition metals (see picture). Among the recent developments are copper-catalyzed asymmetric propargylic amination reactions. Nu = nucleophile © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

propargylic

nucleophilic substitution

acetates

alkynes

enoxysilanes

alkylation

substitution

asymmetric catalysis

amines

transition metals

esters

alcohols

complexes

amination

acetone

nucleophilic-substitution

Författare

N. Ljungdahl

Chalmers University of Technology

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 48 642-644

Ämneskategorier

Fysikalisk kemi

Kemi

DOI

10.1002/anie.200804114