Estimation of the PCR efficiency based on a size-dependent modelling of the amplification process
Journal article, 2005

We propose a stochastic modelling of the PCR amplification process by a size-dependent branching process starting as a supercritical Bienaymé-Galton-Watson transient phase and then having a saturation near-critical size-dependent phase. This model based on the concept of saturation allows one to estimate the probability of replication of a DNA molecule at each cycle of a single PCR trajectory with a very good accuracy.


Nadia Lalam

University of North Texas

C. Jacob

INRA Institut National de La Recherche Agronomique

Peter Jagers

University of Gothenburg

Chalmers, Mathematical Sciences, Mathematical Statistics

Comptes Rendus Mathematique

1631-073X (ISSN)

Vol. 341 10 631-634

Subject Categories

Probability Theory and Statistics



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