Model of gene transcription including the return of a RNA polymerase to the beginning of a transcriptional cycle
Journal article, 2009
The gene transcription occurs via the RNA polymerase (RNAP) recruitment on the DNA promoter sequence, formation of a locally open DNA chain, promoter escape, steps of the RNA synthesis, and RNA and RNAP release after reading the final DNA base. Just after the end of the RNA synthesis, RNAP surrounds the closed DNA chain and may diffuse along DNA, desorb, or reach the promoter and start the RNA-synthesis cycle again. We present a generic kinetic model taking the latter steps into account and show analytically and by Monte Carlo simulations that it predicts transcriptional bursts even in the absence of explicit regulation of the transcription by master proteins.
DNA
protein
initiation
expression
ii transcription
Monte Carlo methods
stochasticity
kinetic theory
macromolecules
genetics
dna
regulatory networks
molecular biophysics
diffusion
coding-rna
elongation
proteins
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Chemical Physics
Physical Review E
24700045 (ISSN) 24700053 (eISSN)
Vol. 80 5 art no 051925 -Subject Categories
Other Physics Topics
Fusion, Plasma and Space Physics
DOI
10.1103/PhysRevE.80.051925