Model of gene transcription including the return of a RNA polymerase to the beginning of a transcriptional cycle
Journal article, 2009

The gene transcription occurs via the RNA polymerase (RNAP) recruitment on the DNA promoter sequence, formation of a locally open DNA chain, promoter escape, steps of the RNA synthesis, and RNA and RNAP release after reading the final DNA base. Just after the end of the RNA synthesis, RNAP surrounds the closed DNA chain and may diffuse along DNA, desorb, or reach the promoter and start the RNA-synthesis cycle again. We present a generic kinetic model taking the latter steps into account and show analytically and by Monte Carlo simulations that it predicts transcriptional bursts even in the absence of explicit regulation of the transcription by master proteins.

DNA

protein

initiation

expression

ii transcription

Monte Carlo methods

stochasticity

kinetic theory

macromolecules

genetics

dna

regulatory networks

molecular biophysics

diffusion

coding-rna

elongation

proteins

Author

Vladimir Zhdanov

Chalmers, Applied Physics, Chemical Physics

Physical Review E

24700045 (ISSN) 24700053 (eISSN)

Vol. 80 5 art no 051925 -

Subject Categories

Other Physics Topics

Fusion, Plasma and Space Physics

DOI

10.1103/PhysRevE.80.051925

More information

Created

10/6/2017