Model of gene transcription including the return of a RNA polymerase to the beginning of a transcriptional cycle
Artikel i vetenskaplig tidskrift, 2009

The gene transcription occurs via the RNA polymerase (RNAP) recruitment on the DNA promoter sequence, formation of a locally open DNA chain, promoter escape, steps of the RNA synthesis, and RNA and RNAP release after reading the final DNA base. Just after the end of the RNA synthesis, RNAP surrounds the closed DNA chain and may diffuse along DNA, desorb, or reach the promoter and start the RNA-synthesis cycle again. We present a generic kinetic model taking the latter steps into account and show analytically and by Monte Carlo simulations that it predicts transcriptional bursts even in the absence of explicit regulation of the transcription by master proteins.

DNA

protein

initiation

expression

ii transcription

Monte Carlo methods

stochasticity

kinetic theory

macromolecules

genetics

dna

regulatory networks

molecular biophysics

diffusion

coding-rna

elongation

proteins

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Kemisk fysik

Physical Review E - Statistical, Nonlinear, and Soft Matter Physics

1539-3755 (ISSN)

Vol. 80 art no 051925 -

Ämneskategorier

Annan fysik

Fusion, plasma och rymdfysik

DOI

10.1103/PhysRevE.80.051925