ncRNA-mediated bistability in the synthesis of hundreds of distinct mRNAs and proteins
Journal article, 2010
The kinetics of gene expression can be bistable due to the feedback between the mRNA and protein formation. In eukaryotic cells, the interplay between mRNAs and proteins can be influenced by non-coding RNAs. Some of these RNAs, e.g., microRNAs, may target hundreds of distinct mRNAs. The model presented here shows how a non-coding RNA can be used as a mediator in order to involve numerous mRNAs and proteins into a bistable network.
Bifurcations
mRNA
Subcellular processes
mRNA translation
ncRNA and protein degradation
Mean-field kinetic equations
ncRNA-mRNA association
mRNA and ncRNA synthesis
Gene transcription
Author
Vladimir Zhdanov
Chalmers, Applied Physics, Biological Physics
Physica A: Statistical Mechanics and its Applications
0378-4371 (ISSN)
Vol. 389 4 887-890Subject Categories
Condensed Matter Physics
DOI
10.1016/j.physa.2009.11.028