ncRNA-mediated bistability in the synthesis of hundreds of distinct mRNAs and proteins
Artikel i vetenskaplig tidskrift, 2010

The kinetics of gene expression can be bistable due to the feedback between the mRNA and protein formation. In eukaryotic cells, the interplay between mRNAs and proteins can be influenced by non-coding RNAs. Some of these RNAs, e.g., microRNAs, may target hundreds of distinct mRNAs. The model presented here shows how a non-coding RNA can be used as a mediator in order to involve numerous mRNAs and proteins into a bistable network.

Bifurcations

mRNA

Subcellular processes

mRNA translation

ncRNA and protein degradation

Mean-field kinetic equations

ncRNA-mRNA association

mRNA and ncRNA synthesis

Gene transcription

Författare

Vladimir Zhdanov

Chalmers, Teknisk fysik, Biologisk fysik

Physica A: Statistical Mechanics and its Applications

0378-4371 (ISSN)

Vol. 389 4 887-890

Ämneskategorier

Den kondenserade materiens fysik

DOI

10.1016/j.physa.2009.11.028