Cocatalytic Enzyme System for the Michael Addition Reaction of in-situ-Generated ortho-Quinones
Journal article, 2009

A laccase-lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3-dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products.

laccase

Laccase

Lipase

Cascade reaction

Quinones

acid

Michael addition

formation

3 consecutive biotransformations

carbon bond

benzofuran

one-pot synthesis

derivatives

electrochemical oxidation

fully aqueous-medium

cascade reactions

Enzyme catalysis

lipase

Author

S. Witayakran

Georgia Institute of Technology

Art Ragauskas

Chalmers, Chemical and Biological Engineering, Forest Products and Chemical Engineering

European Journal of Organic Chemistry

1434-193X (ISSN)

3 358-363

Subject Categories

Other Engineering and Technologies not elsewhere specified

DOI

10.1002/ejoc.200800791

More information

Created

10/7/2017