Cocatalytic Enzyme System for the Michael Addition Reaction of in-situ-Generated ortho-Quinones
Artikel i vetenskaplig tidskrift, 2009

A laccase-lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3-dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products.

laccase

Laccase

Lipase

Cascade reaction

Quinones

acid

Michael addition

formation

3 consecutive biotransformations

carbon bond

benzofuran

one-pot synthesis

derivatives

electrochemical oxidation

fully aqueous-medium

cascade reactions

Enzyme catalysis

lipase

Författare

S. Witayakran

Georgia Institute of Technology

Art Ragauskas

Chalmers, Kemi- och bioteknik, Skogsindustriell kemiteknik

European Journal of Organic Chemistry

1434-193X (ISSN)

358-363

Ämneskategorier

Övrig annan teknik

DOI

10.1002/ejoc.200800791