Cocatalytic Enzyme System for the Michael Addition Reaction of in-situ-Generated ortho-Quinones
Artikel i vetenskaplig tidskrift, 2009
A laccase-lipase cocatalytic system was used to catalyze the domino reaction between catechols and nucleophilic reagents including 1,3-dicarbonyl compounds and aromatic amines in aqueous medium at room temperature. Lipase acted as a catalyst for Michael addition step, and also enhanced the overall yield of the final products.
laccase
Laccase
Lipase
Cascade reaction
Quinones
acid
Michael addition
formation
3 consecutive biotransformations
carbon bond
benzofuran
one-pot synthesis
derivatives
electrochemical oxidation
fully aqueous-medium
cascade reactions
Enzyme catalysis
lipase
Författare
S. Witayakran
Georgia Institute of Technology
Art Ragauskas
Chalmers, Kemi- och bioteknik, Skogsindustriell kemiteknik
European Journal of Organic Chemistry
1434-193X (ISSN) 10990690 (eISSN)
3 358-363Ämneskategorier
Övrig annan teknik
DOI
10.1002/ejoc.200800791