Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate
Journal article, 2009
The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.
phase-behavior
ussing chamber
mixed micelles
counterion binding
in-vitro
drug-delivery systems
self-emulsifying drug-delivery system
microemulsion
diffusion
cationic amphiphile
light-scattering
mucin
gastrointestinal mucus
Bioavailability
nonionic surfactant
Author
Dan Lundberg
Chalmers, Chemical and Biological Engineering, Applied Surface Chemistry
G. Lafitte
Lund University
H. Ljusberg-Wahren
Lund University
P. Lennernas
Camurus AB
K. Thuresson
Camurus AB
Journal of Dispersion Science and Technology
0193-2691 (ISSN) 1532-2351 (eISSN)
Vol. 30 6 920-928Subject Categories
Physical Chemistry
DOI
10.1080/01932690802646264