Studies on the Interactions Between Mucin and Surfactant Aggregates Containing the Cationic Surfactant Dodecyl Betainate
Artikel i vetenskaplig tidskrift, 2009

The interactions of surfactant aggregates containing the cationic, cleavable surfactant dodecyl betainate (DB) with mucin are investigated. The aggregates were either mixed micelles of DB and the nonionic surfactant PS-80 in different ratios or a dispersion of the commercial self-emulsifying drug-delivery formulation Sandimmun Neoral charged with DB. It is found that for the surfactant aggregates to show any notable interactions with mucin these must have a high positive charge density. Also presented are results from Ussing chamber experiments, which suggest that DB has a limited impact on the integrity and the barrier function of the intestinal epithelium.

phase-behavior

ussing chamber

mixed micelles

counterion binding

in-vitro

drug-delivery systems

self-emulsifying drug-delivery system

microemulsion

diffusion

cationic amphiphile

light-scattering

mucin

gastrointestinal mucus

Bioavailability

nonionic surfactant

Författare

Dan Lundberg

Chalmers, Kemi- och bioteknik, Teknisk ytkemi

G. Lafitte

Lunds universitet

H. Ljusberg-Wahren

Lunds universitet

P. Lennernas

Camurus AB

K. Thuresson

Camurus AB

Journal of Dispersion Science and Technology

0193-2691 (ISSN) 1532-2351 (eISSN)

Vol. 30 6 920-928

Ämneskategorier

Fysikalisk kemi

DOI

10.1080/01932690802646264