Analytical approaches to investigate transmitter content and release from single secretory vesicles
Journal article, 2010

The vesicle serves as the primary intracellular unit for the highly efficient storage and release of chemical messengers triggered during signaling processes in the nervous system. This review highlights conventional and emerging analytical methods that have used microscopy, electrochemistry, and spectroscopy to resolve the location, time course, and quantal content characteristics of neurotransmitter release. Particular focus is on the investigation of the synaptic vesicle and its involvement in the fundamental molecular mechanisms of cell communication.

Vesicle . Exocytosis . Neurotransmitter . Carbon-fiber amperometry . Electrochemical cytometry. Capillary electrophoresis


D. M. Omiatek

Pennsylvania State University

Ann-Sofie Cans

Chalmers, Chemical and Biological Engineering, Physical Chemistry

M. L. Heien

Pennsylvania State University

Andrew Ewing

University of Gothenburg

Analytical and Bioanalytical Chemistry

1618-2642 (ISSN) 1618-2650 (eISSN)

Vol. 397 8 3269-3279

Subject Categories

Inorganic Chemistry

Analytical Chemistry




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