Ann-Sofie Cans

Associate Professor at Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry

At Chalmers I am now pioneering a research program with a focus on nanosensor engineering and artificial cell structures to study the chemistry and biophysics of cells, and neuronal communication. Currently running projects involve development and application of artificial cell models to study 1) quantitative amperometric measurements on the effects of lipids composition in membrane dynamics and sorting inhigh curvature regions of nanotube biomembranes, 2) DNA-zipper-catalyzed artificial exocytosis, and 3) development of millisecond time resolved ultra-small biosensors constructed from enzyme nanoparticle bioconjugates for selective probing of molecules in vivo in the brain.

Source: chalmers.se

Showing 39 publications

2019

Ultrafast Glutamate Biosensor Recordings in Brain Slices Reveal Complex Single Exocytosis Transients

Yuanmo Wang, Devesh Mishra, Jenny Bergman et al
ACS Chemical Neuroscience. Vol. 10 (3), p. 1744-1752
Journal article
2018

Co-detection of dopamine and glucose with high temporal resolution

Jenny Bergman, Lisa Mellander, Yuanmo Wang et al
Catalysts. Vol. 8 (1)
Journal article
2018

Membrane Remodeling of Giant Vesicles in Response to Localized Calcium Ion Gradients

Baharan Ali Doosti, Ann-Sofie Cans, Gavin Jeffries et al
Journal of Visualized Experiments (137)
Journal article
2018

Counting the number of enzymes immobilized onto a nanoparticle-coated electrode

Jenny Bergman, Yuanmo Wang, Joakim Wigström et al
Analytical and Bioanalytical Chemistry. Vol. 410 (6), p. 1775-1783
Journal article
2018

Monitoring the effect of osmotic stress on secretory vesicles and exocytosis

Hoda Mashadi Fathali, Johan Dunevall, Soodabeh Majdi et al
Journal of Visualized Experiments. Vol. 2018 (132)
Journal article
2018

Amperometry methods for monitoring vesicular quantal size and regulation of exocytosis release

Hoda Mashadi Fathali, Ann-Sofie Cans
Pflugers Archiv European Journal of Physiology. Vol. 470 (1), p. 125-134
Review article
2017

Extracellular Osmotic Stress Reduces the Vesicle Size while Keeping a Constant Neurotransmitter Concentration

Hoda Mashadi Fathali, Johan Dunevall, Soodabeh Majdi et al
ACS Chemical Neuroscience. Vol. 8 (2), p. 368-375
Journal article
2016

Lithographic Microfabrication of a 16-Electrode Array on a Probe Tip for High Spatial Resolution Electrochemical Localization of Exocytosis

Joakim Wigström, Johan Dunevall, Neda Najafinobar et al
Analytical Chemistry. Vol. 88 (4), p. 2080-2087
Journal article
2016

The evidence for open and closed exocytosis as the primary release mechanism

Lin Ren, Lisa Mellander, Jacqueline Keighron et al
Quarterly Reviews of Biophysics. Vol. 49
Journal article
2016

Excited Fluorophores Enhance the Opening of Vesicles at Electrode Surfaces in Vesicle Electrochemical Cytometry

Neda Najafinobar, Jelena Lovric, Soodabeh Majdi et al
Angewandte Chemie - International Edition. Vol. 55 (48), p. 15081-15085
Journal article
2016

Cholesterol Alters the Dynamics of Release in Protein Independent Cell Models for Exocytosis

Neda Najafinobar, Lisa Mellander, Michael Kurczy et al
Scientific Reports. Vol. 6 (Article number: 33702)
Journal article
2016

Development of Ultra-Fast Nanostructured Glucose Biosensor - Stoichiometry and Activity

Yuanmo Wang, Ann-Sofie Cans
Biophysical Journal. Vol. 110 (3), p. 429A-429A
Magazine article
2015

Millisecond Time Resolved Electrochemical Detection of Non-Electroactive Neurotransmitter Release

Ann-Sofie Cans, Jacqueline Keighron, Michael Kurczy et al
Biophysical Journal. Vol. 108 (2), p. 481A-481A
Conference contribution
2015

Amperometric Detection of Single Vesicle Acetylcholine Release Events from an Artificial Cell

Jacqueline Keighron, Joakim Wigström, Michael Kurczy et al
ACS Chemical Neuroscience. Vol. 6 (1), p. 181-188
Journal article
2015

The Effect of Excited Fluorophore on Vesicle Fusion at the Surface of the Electrode

Neda Najafinobar, Johan Dunevall, Jelena Lovric et al
Biophysical Journal. Vol. 108 (2), p. 239A-239A
Conference contribution
2015

Characterizing the Catecholamine Content of Single Mammalian Vesicles by Collision-Adsorption Events at an Electrode

Johan Dunevall, Hoda Mashadi Fathali, Neda Najafinobar et al
Journal of the American Chemical Society. Vol. 137 (13), p. 4344-4346
Journal article
2014

Using a Cell Model to Study the Effect of Cholesterol on Exocytosis

Neda Najafinobar, L. Mellander, Michael Kurczy et al
Biophysical Journal. Vol. 106 (2), p. 628A-628A
Magazine article
2014

Two modes of exocytosis in an artificial cell

Lisa Mellander, Michael Kurczy, Neda Najafinobar et al
Scientific Reports. Vol. 4, p. (article nr.) 3847-
Journal article
2014

Electrochemcial Detection of Acetylcholine using Enzyme Functionalized Nanoparticles

Jacqueline Keighron, Michael Kurczy, Joakim Wigström et al
Biophysical Journal. Vol. 106 (2), p. 416A-416A
Magazine article
2014

Composition Based Strategies for Controlling Radii in Lipid Nanotubes

Michael Kurczy, Lisa Mellander, Neda Najafinobar et al
PLoS ONE. Vol. 9 (1), p. Art.no. e81293-
Journal article
2014

Coimmobilization of Acetylcholinesterase and Choline Oxidase on Gold Nanoparticles: Stoichiometry, Activity, and Reaction Efficiency

Jacqueline Keighron, Sebastian Åkesson, Ann-Sofie Cans
Langmuir. Vol. 30 (38), p. 11348-11355
Journal article
2014

The Role of Dense Core Nanoparticles in Regulation of Neuronal Communication

Hoda Mashadi Fathali, Jacqueline Keighron, Ann-Sofie Cans
Biophysical Journal. Vol. 106 (2), p. 526A-526A
Magazine article
2013

A Secretory Artificial Cell for Exocytosis

Ann-Sofie Cans, Lisa Simonsson, Michael Kurczy et al
Biophysical Journal. Vol. 104 (2 Suppl 1), p. 621A-622A
Conference poster
2013

The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry

D. M. Omiatek, A. J. Bressler, Ann-Sofie Cans et al
Scientific Reports. Vol. 3, p. artikel nr 1447-
Journal article
2012

Analytical tools to monitor exocytosis: A focus on new fluorescent probes and methods

Jacqueline Keighron, Andrew Ewing, Ann-Sofie Cans
The Analyst. Vol. 137 (8), p. 1755-1763
Journal article
2012

Highlights of selected recent electrochemical measurements in living systems

R. Trouillon, M. I. Svensson, E. C. Berglund et al
Electrochimica Acta. Vol. 84, p. 84-95
Journal article
2012

A functioning artificial secretory cell

Lisa Simonsson, Michael Kurczy, R. Trouillon et al
Scientific Reports. Vol. 2, p. no. 824-
Journal article
2012

Carbon-Ring Microelectrode Arrays for Electrochemical Imaging of Single Cell Exocytosis: Fabrication and Characterization

Y. Q. Lin, R. Trouillon, M. I. Svensson et al
Analytical Chemistry. Vol. 84 (6), p. 2949-2954
Journal article
2011

Highlights of 20 years of electrochemical measurements of exocytosis at cells and artificial cells

Ann-Sofie Cans, Andrew Ewing
Journal of Solid State Electrochemistry. Vol. 15 (7-8), p. 1437-1450
Journal article
2011

Mechanics of lipid bilayer junctions affecting the size of a connecting lipid nanotube

Roger Karlsson, Michael Kurczy, Richards Grzhibovskis et al
Nanoscale Research Letters. Vol. 6, p. 1-6
Journal article
2010

Steady-State Electrochemical Determination of Lipidic Nanotube Diameter Utilizing an Artificial Cell Model

Kelly L. Adams, Johan Engelbrektsson, Marina Voinova et al
Analytical Chemistry. Vol. 82 (3), p. 1020-1026
Journal article
2010

Electrochemical Probes for Spatial Detection of Exocytosis and Vesicles

Lisa Mellander, Ann-Sofie Cans, Andrew Ewing
ChemPhysChem. Vol. 11 (13), p. 2756-2763
Journal article
2010

Analytical approaches to investigate transmitter content and release from single secretory vesicles

D. M. Omiatek, Ann-Sofie Cans, M. L. Heien et al
Analytical and Bioanalytical Chemistry. Vol. 397 (8), p. 3269-3279
Journal article
2010

Tools to monitor exocytosis: a focus on new fluorescent probes and methods

Ann-Sofie Cans, Andrew Ewing
Cellscience Reviews. Vol. 6 (3), p. 104-22
Journal article
2008

Budding and asymmetric protein microcompartmentation in giant vesicles containing two aqueous phases

M. S. Long, Ann-Sofie Cans, C. D. Keating
Journal of the American Chemical Society. Vol. 130 (2), p. 756-762
Journal article
2008

Positioning lipid membrane domains in giant vesicles by micro-organization of aqueous cytoplasm mimic

Ann-Sofie Cans, M. Andes-Koback, C. D. Keating
Journal of the American Chemical Society. Vol. 130 (23), p. 7400-7406
Journal article
2004

The effects of vesicular volume on secretion through the fusion pore in exocytotic release from PC12 cells

L.A. Sombers, H.J. Hanchar, T.L. Colliver et al
Journal of Neuroscience. Vol. 24 (2), p. 303-309
Journal article
2001

Micropipet-assisted formation of microscopic networks of unilamellar lipid bilayer nanotubes and containers

Mattias Karlsson, Kristin Sott, Ann-Sofie Cans et al
Langmuir. Vol. 17 (22), p. 6754-6758
Journal article
2001

Measurement of the Dynamics of Exocytosis and Vesicle Retrieval at Cell Populations using a Quartz Crystal Microbalance

Ann-Sofie Cans, Fredrik Höök, Oleg Shupliakov et al
Analytical Chemistry. Vol. 73, p. 5805-5811
Journal article

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