Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré
Journal article, 2010

Background: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst”) in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003). Conclusion: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS

severity

oxygen radical production

RGBS

Author

Natalia Mossberg

University of Gothenburg

Oluf Andersen

University of Gothenburg

Magnus Nordin

University of Gothenburg

Staffan Nilsson

Chalmers, Mathematical Sciences, Mathematical Statistics

University of Gothenburg

Åke Svedhem

University of Gothenburg

Tomas Bergström

University of Gothenburg

Kristoffer Hellstrand

University of Gothenburg

Charlotta Movitz

University of Gothenburg

Journal of Inflammation

1476-9255 (eISSN)

Vol. 7 Art nr. 40- 40

Subject Categories

Microbiology in the medical area

DOI

10.1186/1476-9255-7-40

More information

Latest update

4/5/2022 6