Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré
Artikel i vetenskaplig tidskrift, 2010

Background: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst”) in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003). Conclusion: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS

severity

oxygen radical production

RGBS

Författare

Natalia Mossberg

Göteborgs universitet

Oluf Andersen

Göteborgs universitet

Magnus Nordin

Göteborgs universitet

Staffan Nilsson

Chalmers, Matematiska vetenskaper, matematisk statistik

Göteborgs universitet

Åke Svedhem

Göteborgs universitet

Tomas Bergström

Göteborgs universitet

Kristoffer Hellstrand

Göteborgs universitet

Charlotta Movitz

Göteborgs universitet

Journal of Inflammation

1476-9255 (eISSN)

Vol. 7 Art nr. 40-

Ämneskategorier

Mikrobiologi inom det medicinska området

DOI

10.1186/1476-9255-7-40