Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
Journal article, 2010

We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption.

electron

dependence

transfer

membrane

porphyrin

supramolecular

DNA

nanotechnology

construction

scaffold

bridge-acceptor systems

flow

orientation

fluorescence

dichroism

liposomes

membrane

photoinduced electron-transfer

Author

Karl Börjesson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Joanna Wiberg

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Afaf El-Sagheer

University of Southampton

Suez Canal University

Thomas Ljungdahl

University of Gothenburg

Jerker Mårtensson

Chalmers, Chemical and Biological Engineering, Organic Chemistry

T. Brown

University of Southampton

Bengt Nordén

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Bo Albinsson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

ACS Nano

1936-0851 (ISSN) 1936-086X (eISSN)

Vol. 4 9 5037-5046

Areas of Advance

Nanoscience and Nanotechnology (2010-2017)

Energy

Life Science Engineering (2010-2018)

Materials Science

Subject Categories

Chemical Sciences

DOI

10.1021/nn100667b

More information

Latest update

2/28/2018