Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
Artikel i vetenskaplig tidskrift, 2010

We have synthesized and studied a supramolecular system comprising a 39-mer DNA with porphyrin-modified thymidine nucleosides anchored to the surface of large unilamellar vesicles (liposomes). Liposome porphyrin binding characteristics, such as orientation, strength, homogeneity, and binding site size, was determined, suggesting that the porphyrin is well suited as a photophysical and redox-active lipid anchor, in comparison to the inert cholesterol anchor commonly used today. Furthermore, the binding characteristics and hybridization capabilities were studied as a function of anchor size and number of anchoring points, properties that are of importance for our future plans to use the addressability of these redox-active nodes in larger DNA-based nanoconstructs. Electron transfer from photoexcited porphyrin to a lipophilic benzoquinone residing in the lipid membrane was characterized by steady-state and time-resolved fluorescence and verified by femtosecond transient absorption.

electron

dependence

transfer

membrane

porphyrin

supramolecular

DNA

nanotechnology

construction

scaffold

bridge-acceptor systems

flow

orientation

fluorescence

dichroism

liposomes

membrane

photoinduced electron-transfer

Författare

Karl Börjesson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Joanna Wiberg

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Afaf El-Sagheer

University of Southampton

Suez Canal University

Thomas Ljungdahl

Göteborgs universitet

Jerker Mårtensson

Chalmers, Kemi- och bioteknik, Organisk kemi

T. Brown

University of Southampton

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Bo Albinsson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

ACS Nano

1936-0851 (ISSN) 1936-086X (eISSN)

Vol. 4 9 5037-5046

Styrkeområden

Nanovetenskap och nanoteknik

Energi

Livsvetenskaper och teknik

Materialvetenskap

Ämneskategorier

Kemi

DOI

10.1021/nn100667b