A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging
Journal article, 2010
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved.
ALE
erosion
glassy-polymers
Dissolution
reptation
Mathematical modelling
MRI
poly(ethylene oxide)
drug-delivery
hpmc matrices
mathematical-models
release
Polyethylene oxide
diffusion
rubbery
Author
E. Kaunisto
Lund University
Susanna Abrahmsén-Alami
AstraZeneca AB
P. Borgquist
Gambro AB
Anette Larsson
SuMo Biomaterials
Chalmers, Chemical and Biological Engineering, Pharmaceutical Technology
B. Nilsson
Lund University
A. Axelsson
Lund University
Journal of Controlled Release
0168-3659 (ISSN) 18734995 (eISSN)
Vol. 147 2 232-241Subject Categories
Chemical Sciences
DOI
10.1016/j.jconrel.2010.07.102