A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging
Artikel i vetenskaplig tidskrift, 2010
In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved.
ALE
erosion
glassy-polymers
Dissolution
reptation
Mathematical modelling
MRI
poly(ethylene oxide)
drug-delivery
hpmc matrices
mathematical-models
release
Polyethylene oxide
diffusion
rubbery
Författare
E. Kaunisto
Lunds universitet
Susanna Abrahmsén-Alami
AstraZeneca AB
P. Borgquist
Gambro AB
Anette Larsson
SuMo Biomaterials
Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi
B. Nilsson
Lunds universitet
A. Axelsson
Lunds universitet
Journal of Controlled Release
0168-3659 (ISSN) 18734995 (eISSN)
Vol. 147 2 232-241Ämneskategorier
Kemi
DOI
10.1016/j.jconrel.2010.07.102