A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging
Artikel i vetenskaplig tidskrift, 2010

In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved.

release

hpmc matrices

MRI

glassy-polymers

Polyethylene oxide

diffusion

poly(ethylene oxide)

mathematical-models

reptation

erosion

Dissolution

drug-delivery

Mathematical modelling

ALE

rubbery

Författare

E. Kaunisto

Lunds universitet

Susanna Abrahmsén-Alami

AstraZeneca AB

P. Borgquist

Gambro AB

Anette Larsson

SuMo Biomaterials

Chalmers, Kemi- och bioteknik, Farmaceutisk teknologi

B. Nilsson

Lunds universitet

A. Axelsson

Lunds universitet

Journal of Controlled Release

0168-3659 (ISSN)

Vol. 147 232-241

Ämneskategorier

Kemi

DOI

10.1016/j.jconrel.2010.07.102