HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.
Journal article, 2010
Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy regimens in relation to intrathecal immune activation and central nervous system penetration effectiveness (CPE) rank.
virology
Blood-Brain Barrier
Male
Cerebrospinal Fluid
Enzyme-Linked Immunosorbent Assay
Middle Aged
HIV Infections
HIV-1
isolation & purification
Female
Cross-Sectional Studies
virology
Neopterin
drug therapy
virology
Humans
Reverse Transcriptase Polymerase Chain Reaction
Treatment Outcome
Viral Load
Anti-HIV Agents
isolation & purification
Viral
Plasma
analysis
RNA
Author
Arvid Edén
University of Gothenburg
Dietmar Fuchs
Medical University of Innsbruck
Lars Hagberg
University of Gothenburg
Staffan Nilsson
University of Gothenburg
Chalmers, Mathematical Sciences, Mathematical Statistics
Serena Spudich
University of California
Bo Svennerholm
University of Gothenburg
R.W. Price
University of California
Magnus Gisslén
University of Gothenburg
Journal of Infectious Diseases
0022-1899 (ISSN) 1537-6613 (eISSN)
Vol. 202 12 1819-25Subject Categories
Infectious Medicine
DOI
10.1086/657342
PubMed
21050119