HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.
Artikel i vetenskaplig tidskrift, 2010

Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy regimens in relation to intrathecal immune activation and central nervous system penetration effectiveness (CPE) rank.

virology

Blood-Brain Barrier

Male

Cerebrospinal Fluid

Enzyme-Linked Immunosorbent Assay

Middle Aged

HIV Infections

HIV-1

isolation & purification

Female

Cross-Sectional Studies

virology

Neopterin

drug therapy

virology

Humans

Reverse Transcriptase Polymerase Chain Reaction

Treatment Outcome

Viral Load

Anti-HIV Agents

isolation & purification

Viral

Plasma

analysis

RNA

Författare

Arvid Edén

Göteborgs universitet

Dietmar Fuchs

Medizinische Universitat Innsbruck

Lars Hagberg

Göteborgs universitet

Staffan Nilsson

Göteborgs universitet

Chalmers, Matematiska vetenskaper, matematisk statistik

Serena Spudich

University of California

Bo Svennerholm

Göteborgs universitet

R.W. Price

University of California

Magnus Gisslén

Göteborgs universitet

Journal of Infectious Diseases

0022-1899 (ISSN) 1537-6613 (eISSN)

Vol. 202 12 1819-25

Ämneskategorier

Infektionsmedicin

PubMed

21050119