Magnetically Triggered Release From Giant Unilamellar Vesicles: Visualization By Means Of Confocal Microscopy
Journal article, 2011

Magnetically triggered release from magnetic giant unilamellar vesicles (GUVs) loaded with Alexa fluorescent dye was studied by means of confocal laser scanning microscopy (CLSM) under a low-frequency alternating magnetic field (LF-AMP). Core/shell cobalt ferrite nanoparticles coated with rhodamine B isothiocyanate (MP@SiO2(RITC)) were prepared and adsorbed on the GUV membrane. The MP@SiO2-(RITC) location and distribution on giant lipid vesicles were determined by 3D-CLSM projections, and their effect on the release properties and GUV permeability under a LF-AMF was investigated by CLSM time-resolved experiments. We show that the mechanism of release of the fluorescent dye during the LF-AMF exposure is induced by magnetic nanoparticle energy and mechanical vibration, which promote the perturbation of the GUV membrane without its collapse.

delivery systems

drug-release

quantum dots

controlled

fluid-loaded liposomes

iron-oxide nanoparticles

surfactant

magnetoliposomes

stabilization

field

cobalt-ferrite nanoparticles

Author

S. Nappini

University of Florence

T. Al Kayal

University of Florence

D. Berti

University of Florence

Bengt Nordén

Chalmers, Chemical and Biological Engineering, Physical Chemistry

P. Baglioni

University of Florence

Journal of Physical Chemistry Letters

1948-7185 (eISSN)

Vol. 2 7 713-718

Areas of Advance

Nanoscience and Nanotechnology (2010-2017)

Energy

Life Science Engineering (2010-2018)

Materials Science

Subject Categories

Chemical Sciences

DOI

10.1021/jz2000936

More information

Latest update

3/2/2018 7