Magnetically Triggered Release From Giant Unilamellar Vesicles: Visualization By Means Of Confocal Microscopy
Artikel i vetenskaplig tidskrift, 2011

Magnetically triggered release from magnetic giant unilamellar vesicles (GUVs) loaded with Alexa fluorescent dye was studied by means of confocal laser scanning microscopy (CLSM) under a low-frequency alternating magnetic field (LF-AMP). Core/shell cobalt ferrite nanoparticles coated with rhodamine B isothiocyanate (MP@SiO2(RITC)) were prepared and adsorbed on the GUV membrane. The MP@SiO2-(RITC) location and distribution on giant lipid vesicles were determined by 3D-CLSM projections, and their effect on the release properties and GUV permeability under a LF-AMF was investigated by CLSM time-resolved experiments. We show that the mechanism of release of the fluorescent dye during the LF-AMF exposure is induced by magnetic nanoparticle energy and mechanical vibration, which promote the perturbation of the GUV membrane without its collapse.

delivery systems

drug-release

quantum dots

controlled

fluid-loaded liposomes

iron-oxide nanoparticles

surfactant

magnetoliposomes

stabilization

field

cobalt-ferrite nanoparticles

Författare

S. Nappini

Universita degli Studi di Firenze

T. Al Kayal

Universita degli Studi di Firenze

D. Berti

Universita degli Studi di Firenze

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

P. Baglioni

Universita degli Studi di Firenze

Journal of Physical Chemistry Letters

1948-7185 (eISSN)

Vol. 2 713-718

Styrkeområden

Nanovetenskap och nanoteknik

Energi

Livsvetenskaper och teknik

Materialvetenskap

Ämneskategorier

Kemi

DOI

10.1021/jz2000936