Bengt Nordén
Jag är nog intresserad av det mesta som rör sig: från att grubbla över livets uppkomst - och om det skedde utanför jorden - till hur en electron rör sig i en atom eller hur ett elektriskt fält utanför en jon kan katalysera en kemisk reaktion. Även om mina forskningsprojekt alla gäller nyfikenhetsdriven grundforskning finns nästan alltid någon intressant praktisk vinkling. Studier av hur molekyler ordnas i en strömmande vätska gav oss t ex en metod att studera protein- och DNA-struktur i lösning, en uppfinning som vi dagligen använder oss av. Undersökningar av hur olika ämnen tar sig igenom ett lipid-membran är ett annat exempel: de kan leda till nya strategier för att få avancerade läkermedel in i levande celler o s v.
I och med de stora anslagen under 2008 (KAUST Award, Advanced Researcher ERC Grant och Linné-centret Bio-inspired Supramolecular Function and Design) har jag kunnat starta några projekt som jag tidigare bara kunna drömma om. De gäller vitt skilda problemställningar men ofta utnyttjande gemensamma kunskapsbaser: DNA studeras sålunda både ur biologiskt relevanta synvinklar (t ex nya principer för igenkänning av långa sekvenser, mekanismer för genetisk rekombination, genterapi och transfektion), men också för att kunna utnyttja dess basspecificitet och strukturella robusthet för att konstruera “adresserbara” tvådimensionella nätverk för nanotekniska tillämpningar (sensorer, molekyär elektronik, nano-motorer). Spektroskopi är en annan arbetshäst som vi använder i en rad känsliga metoder som vi förfinat för analys av struktur och funktion hos de molekylära systemen.
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Visar 508 publikationer
The Future of Chemistry Through Computations
Large-scale photonic network with squeezed vacuum states for molecular vibronic spectroscopy
Linear Dichroism Measurements for the Study of Protein-DNA Interactions
Nobel Prize 2022 to Sharpless, Meldal, Bertozzi Click Chemistry - molecular lego
Mitigating Climate Changes: A Global Approach
Ska vi verkligen ge Astra Zenecas vaccin till äldre?
The Mole, Avogadro’s Number and Albert Einstein
Mismatch detection in homologous strand exchange amplified by hydrophobic effects
Obegripligt att regeringen vill öppna skolor
Which are the 'Hilbert Problems' of Biophysics?
Michler's hydrol blue elucidates structural differences in prion strains
Understanding Rad51 function is a prerequisite for progress in cancer research
Entangled photons from single atoms and molecules
Linear and circular dichroism characterization of thionine binding mode with DNA polynucleotides
Structural Heterogeneity in Polynucleotide-Facilitated Assembly of Phenothiazine Dyes
Lysozyme's lectin-like characteristics facilitates its immune defense function
A stretched conformation of DNA with a biological role?
Probing Microscopic Orientation in Membranes by Linear Dichroism
Quantum entanglement: facts and fiction - how wrong was Einstein after all?
Polarized Spectroscopy with Fluorescent Biomolecular Building Blocks
A thermodynamic metric for assessing sustainable use of natural resources
ATP Hydrolysis in the RecA-DNA Filament Promotes Structural Changes at the Protein-DNA Interface
Evidence for hydrophobic catalysis of DNA strand exchange
UV Transition Moments of Tyrosine
Identification and characterization of a novel cell penetrating peptide derived from human Oct4
Peptides from RuAAC- Derived 1,5-Disubstituted Triazole Units
Enhanced Cellular Uptake of Antisecretory Peptide AF-16 through Proteoglycan Binding
Characterization of a novel cell penetrating peptide derived from human Oct4
Characterization of a novel cell penetrating peptide derived from human Oct4
Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity
Shear-Induced Membrane Fusion in Viscous Solutions
Controlling and Monitoring Orientation of DNA Nanoconstructs on Lipid Surfaces
Minor-Groove Binding Drugs: Where Is the Second Hoechst 33258 Molecule?
High anisotropy of flow-aligned bicellar membrane systems
Membrane interaction of tryptophan-arginine peptides with dual function
Membrane Interaction and Cellular Uptake of Antisecretory Peptide AF-16
Interactions of a photochromic spiropyran with liposome model membranes
Multiphoton absorption in amyloid protein fibres
Tension Induces a Base-Paired Overstretched DNA Conformation
Spectral Properties and Orientation of Voltage-Sensitive Dyes in Lipid Membranes
Enantiospecific kinking of DNA by a partially intercalating metal complex
Sniffing out early reaction intermediates
Tension induces a base-paired overstretched DNA conformation
Covalent functionalization of carbon nanotube forests grown in situ on a metal-silicon chip
Energy phase shift as mechanism for catalysis
Nonlinear absorption spectra of ethidium and ethidium homodimer
Editorial: The Molecular Frontiers Foundation: Capturing the Interest of Young Minds
Two-photon absorption of metal–organic DNA-probes
Transition State of Rare Event Base Pair Opening Probed by Threading into Looped DNA
Michler's Hydrol Blue: A Sensitive Probe for Amyloid Fibril Detection
Using Ethidium To Probe Nonequilibrium States of DNA Condensed for Gene Delivery
Soft-Surface DNA Nanotechnology: DNA Constructs Anchored and Aligned to Lipid Membrane
DNA in a polyvinyl alcohol matrix and interactions with three intercalating cyanine dyes
Double-lock ratchet mechanism revealing the role of alpha SER-344 in FoF1 ATP synthase
Nanofabrication Yields. Hybridization and Click-Fixation of Polycyclic DNA Nanoassemblies
Magnetoliposomes for controlled drug release in the presence of low-frequency magnetic field
DNA strand exchange catalyzed by molecular crowding in PEG solutions
Functionalized Nanostructures: Redox-Active Porphyrin Anchors for Supramolecular DNA Assemblies
A new fixation strategy for addressable nano-network building blocks
Mechanism of DNA Strand Exchange at Liposome Surfaces Investigated Using Mismatched DNA
Membrane-Anchored DNA Assembly for Energy and Electron Transfer
Physical Rationale Behind the Nonlinear Enthalpy-Entropy Compensation in DNA Duplex Stability
Thermodynamic Aspects of DNA Nanoconstruct Stability and Design
Assigning Membrane Binding Geometry of Cytochrome c by Polarized Light Spectroscopy
Complex DNA binding kinetics resolved-by combined circular dichroism and luminescence analysis
DNA Closed Nanostructures: A Structural and Monte Carlo Simulation Study
Phospholipid membranes decorated by cholesterol-based oligonucleotides as soft hybrid nanostructures
Protein folding as a result of 'self-regulated stochastic resonance': A new paradigm?
Alignment of carbon nanotubes in weak magnetic fields
DNA condensation by PAMAM dendrimers: Self-assembly characteristics and effect on transcription
Enhanced DNA strand exchange on positively charged liposomes
Stimulated endocytosis in penetratin uptake: Effect of arginine and lysine
DNA Polymorphism as an Origin of Adenine-Thymine Tract Length-Dependent Threading Intercalation Rate
Finding at-DNA--kinetic recognition of long adenine-thymine stretches by metal-ligand complexes.
Addressable molecular node assembly - high information density DNA nanostructures
A membrane anchored DNA-based energy/electron transfer assembly
Properties of a bio-photovoltaic nano-device
Luminescent Dipyridophenazine-Ruthenium Probes for Liposome Membranes
Addressable molecular node assembly--functional DNA nanostructures.
Tryptophan Orientation in Model Lipid Membranes
Addressable high-information-density DNA nanostructures
Retinoid chromophores as probes of membrane lipid order
Conformational dynamics of DNA polymerase probed with a novel fluorescent DNA base analogue
Kinetic characterization of an extremely slow DNA binding equilibrium
Enthalpy-entropy compensation: A phantom or something useful?
Triplex addressability as a basis for functional DNA nanostructures
Membrane Interactions of Cell-Penetrating Peptides
Kinetic recognition of AT-rich DNA by ruthenium complexes
Sequence-specific DNA Binding Agents
A polarized-light spectroscopy study of interactions of a hairpin polyamide with DNA
Thermodynamics of PNA Interactions
Membrane destabilizing properties of cell-penetrating peptides
Effects of a hairpin polyamide on DNA melting: Comparison with distamycin and Hoechst 33258
Membrane binding and translocation of cell-penetrating peptides
Vesicle size-dependent translocation of penetratin analogs across lipid membranes
Vesicle membrane interactions of penetratin analogs
Ambivalent Intercalators for DNA: L-Shaped Platinum(II) Complexes
Effects of a hairpin polyamide on DNA melting: comparison with distamycin and Hoechst 33258
Photophysical Characterization of Fluorescent DNA Base Analogue, tC
Uptake of analogs of penetratin, Tat(48-60) and oligoarginine in live cells
ADP Stabilizes the Human Rad51-single stranded DNA Complex and Promotes Its DNA Annealing Activity
Ratchet Device with Broken Friction Symmetry
Arrangement of RecA Protein in Its Active Filament Determined by Polarized-Light Spectroscopy
Genetic screening using the colour change of a PNA-DNA hybrid-binding cyanine dye
Flow Oriented Linear Dichroism to probe Protein Orientation in Membrane Environments
Ratchet due to Broken Friction Symmetry
Formation of DNA Triple Helices by an Oligonucleotide Conjugated to a Fluorescent Ruthenium Complex
Thermodynamics of PNA Interactions with DNA and RNA
DNA as a Catalyst and Catalytic Template for the Racemisation of Metal Tris-Phenanthroline Complexes
Enantioselective DNA Threading Dynamics by Phenazine-Linked [Ru(phen)2dppz]2+ Dimers
A highly fluorescent DNA base analogue that forms Watson-Crick base pairs with guanine
Linear and Circular Dichroism of Drug-Nucleic Acid Complexes
A simple model for gene targeting
Picosecond Time-Resolved Resonance Raman Probing the Light Switch States of [Ru(Phen)2dppz]2+
Influence of DNA on Charge Separation Processes of Ruthenium(II) Complexes
Probing DNA conductivity with photoinduced electron transfer and scanning tunneling microscopy
Thermodynamics of sequence-specific binding of PNA to DNA
Pendulum as a model system for driven rotation in molecular nanoscale machines
Detection of point mutations in DNA by PNA-based quartz-crystal biosensor
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
Electronic spectroscopy: Induced Circular Dichroism
A molecular staple for DNA: Threading bisintercalating D-[Ru(phen)2DPPZ]2+ dimer
In vitro membrane penetration of modified peptide nucleic acid (PNA)
Thermodynamics of PNA-Nucleic Acid Interactions
Soliton and ratchet motions in helices
Binding Mode of Norfloxacin to Calf Thymus DNA
Chromophore Orientation in Liposome Membranes Probed with Flow Dichroism
Coupled-Oscillator Type Derivation of Magnetic Circular Dichroism
Hybridization of peptide nucleic acid
Assignment of electronic transition moment directions of adenine from linear dichroism measurements
Recognition of Double-Stranded DNA by Peptide Nucleic Acids
Electronic transition moments of 2-aminopurine
Observation of a PNA-PNA-PNA triplex
Peptide nucleic acids with a conformationally constrained chiral cyclohexyl-derived backbone
Thermochemical and kinetic evidence for nucleotide-sequence-dependent RecA-DNA interactions
Absence of chiral discrimination in the interaction of tris(diphenanthroline)ruthenium(II) with DNA
Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA
Second-site RecA - DNA interactions: Lack of identical recognition
Direct observation of strand invasion by peptide nucleic acid (PNA) into double-stranded DNA
Ionic effects on the stability and conformation of peptide nucleic acid complexes
Roles of Tyr103 and Tyr264 in the regulation of RecA-DNA interactions by nucleotide cofactors
DNA structural features responsible for sequence-dependent binding geometries of Hoechst 33258
DNA Interactions with Substitution-Inert Transition Metal Ion Complexes
Screening for genetic mutations
Intercalative interactions of ethidium dyes with triplex structures
Induced Chirality in PNA-PNA Duplexes
Shear devices for in situ structural studies of block-copolymer melts and solutions
Phospholipid membrane permeability of peptide nucleic acid
Methylene blue intercalates with triplex poly(dT)*poly(dA)·poly(dT) but not duplex poly(dA)·poly(dT)
Fluorescence-detected interactions of oligonucleotides in RecA complexes
Further Evidence for Binding of Three Single-Stranded DNA Molecules by the RecA Filament
Effects of intercalators on complexation of RecA with duplex DNA
Dancing DNA in Capillary Solution Electrophoresis
Secondary Structure of RecA in Solution - The Effects of Cofactor, DNA and Ionic Conditions
Binding of RecA to anti-parallel poly(dA) · 2poly(dT) triple helix DNA
The cofactor ATP in DNA-RecA complexes is not intercalated between DNA bases
STRUCTURAL CHARACTERIZATION OF PNA-DNA DUPLEXES BY NMR - EVIDENCE FOR DNA IN A B-LIKE CONFORMATION
OPTICAL AND PHOTOPHYSICAL PROPERTIES OF THE OXAZOLE YELLOW DNA PROBES YO AND YOYO
ELECTRONIC-TRANSITION DIPOLE-MOMENTS OF THE 1,N-6-ETHENOADENINE CHROMOPHORE
Interaction of Cationic Porphyrins with DNA
DNA-LIKE DOUBLE HELIX FORMED BY PEPTIDE NUCLEIC-ACID
Analysing DNA complexes by circular and linear dichroism
Electrophoretic orientation of large DNA in free solution
INTERACTIONS OF DNA-BINDING LIGANDS WITH PNA DNA HYBRIDS
Effect of microwave radiation on permeability of liposomes. Evidence against non-thermal leakage
STRUCTURE-ACTIVITY STUDIES OF THE BINDING OF MODIFIED PEPTIDE NUCLEIC-ACIDS (PNAS) TO DNA
BINDING OF DELTA- RU(PHEN)(3) (2+) AND LAMBDA- RU(PHEN)(3) (2+) TO D(CGCGATCGCG) (2) STUDIED BY NMR
INTERACTIONS BETWEEN DNA-MOLECULES BOUND TO RECA FILAMENT - EFFECTS OF BASE COMPLEMENTARITY
BINDING OF DNA QUENCHES TYROSINE FLUORESCENCE OF RECA WITHOUT ENERGY-TRANSFER TO DNA BASES
BINDING OF DAPI ANALOG 2,5-BIS(4-AMIDINOPHENYL)FURAN TO DNA
DNA-BINDING OF DELTA- RU(PHEN)2DPPZ 2+ AND LAMBDA- RU(PHEN)2DPPZ 2+
QUINACRINE - SPECTROSCOPIC PROPERTIES AND INTERACTIONS WITH POLYNUCLEOTIDES
SEQUENCE DEPENDENCE OF 4',6-DIAMIDINO-2-PHENYLINDOLE (DAPI) DNA INTERACTIONS
ORIENTATION OF LARGE DNA DURING FREE SOLUTION ELECTROPHORESIS STUDIED BY LINEAR DICHROISM
ROLE OF TYROSINE RESIDUE-264 OF RECA FOR THE BINDING OF COFACTOR AND DNA
ROLE OF DNA INTERCALATORS IN THE BINDING OF RECA TO DOUBLE-STRANDED DNA
PNA HYBRIDIZES TO COMPLEMENTARY OLIGONUCLEOTIDES OBEYING THE WATSON-CRICK HYDROGEN-BONDING RULES
LOCATION OF EXCIMER-FORMING ADDUCTS OF (+)-ANTI-BENZO A PYRENE DIOL EPOXIDE IN DNA
ACCESSIBILITY TO MODIFICATION OF HISTIDINE-RESIDUES OF RECA PROTEIN UPON DNA AND COFACTOR BINDING
METHYL GREEN - A DNA MAJOR-GROOVE BINDING-DRUG
EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS
Z- B TRANSITION IN POLY D(G-M5C)2 INDUCED BY INTERACTION WITH 4',6-DIAMIDINO-2-PHENYLINDOLE
THE CD OF LIGAND-DNA SYSTEMS .2. POLY(DA-DT) B-DNA
DNA-BINDING AND PHOTOCLEAVAGE BY URANYL(VI) (UO2(2+)) SALTS
Interaction mechanisms of low-level electromagnetic fields in living systems
LINEAR DICHROISM SPECTROSCOPY OF NUCLEIC-ACIDS
IONIC-STRENGTH DEPENDENCE OF THE BINDING OF METHYLENE-BLUE TO CHROMATIN AND CALF THYMUS DNA
COORDINATION OF MULTIPLE DNA-MOLECULES IN RECA FIBER EVIDENCED BY LINEAR DICHROISM SPECTROSCOPY
Excited Electronic States of the Purine Chromophore
ELECTROPHORETIC ORIENTATION OF DNA
DNA INTERACTION WITH CHIRAL METAL-COMPLEXES
THE CD OF LIGAND-DNA SYSTEMS .1. POLY(DG-DC) B-DNA
MICROSCOPIC BEHAVIOR OF DNA DURING ELECTROPHORESIS - ELECTROPHORETIC ORIENTATION
BINDING OF RECA PROTEIN TO Z-FORM DNA STUDIED WITH CIRCULAR AND LINEAR DICHROISM SPECTROSCOPY
INTERACTION OF BENZ A PYRENE DIOL EPOXIDE WITH CHROMATIN STUDIED BY FLOW LINEAR DICHROISM
Preparation of radioactive enantiomers of amino acids using labelled racemates only
Flow linear dichroism supports an accordion model for the salt-induced condensation of chromatin
Characterization of the Spectroscopic Properties of Aromatic-Molecules by Polarized Spectroscopy
Structure of a Covalent Complex Between Benzo(a)Pyrene Diol Epoxide and DNA
Structural properties of the covalent (+)-anti-BPDE-poly(dG-dC)(dG-dC) complex
New Techniques for Aligning Molecules:
Linear Dichroism and Induced Circular Dichroism for Studying Structure and Interactions of DNA
Orientation of DNA during gel electrophoresis studied with linear dichroism spectroscopy
Anthracycline-DNA interactions studied with linear dichroism and fluorescence spectroscopy
Linear Dichroism - A Potential Method for Studying DNA-Protein Interaction.
Critical aspects on optical-Kerr effects of macromolecules. Lack of measurable orientation of DNA
Induced CD of DNA intercalators: Electric dipole allowed transitions
Structure and Dynamics of DNA and DNA-Adduct Complexes Studied with Polarized Light Spectroscopy.
Linear dichroism study of RecA-DNA complexes. Structural evidence and binding stoichiometries
Was natural β radioactivity of carbon-14 the origin of optical one-handedness in life?
Flow orientation of brain microtubules studied by linear dichroism
Enantioselective interactions of inversion-labile trigonal iron(II) complexes upon binding to DNA
Nucleic acid–metal interactions: V. The effect of silver(I) on the structures of A- and B-DNA forms
nteractions between DNA and Psoralenamines Studied with Dichroism Techniques
Conformation and Dynamics of Two Synthetic Deoxyribonucleotide Hexamers of Alternating GC Sequences
Electrophoretic orientation of DNA detected by linear dichroism spectroscopy
Critical Aspects of Measurement of Circular and Linear Dichroism: A Device for Absolute Calibration
Structure of Z-DNA in solution. A flow linear dichroism study
Stepwise unfolding of chromatin by urea: A flow linear dichroism and photoaffinity labeling study
Electrooptical Kerr Effect Studies of Hemoglobin
Structural transitions of chromatin at low salt concentrations: a flow linear dichroism study
The similarity renormalization group for three-body interactions in one dimension
Trisintercalation in DNA by N-[3-(9-Acridinylamino)propyl]-N,N-bis[6-(9- acridinylamino) hexyllamine
Effects of Ag+ and Hg2+ on the structure of DNA in solution studied by flow linear dichroism
Optical activity of bis(thiocarbamide)bis(amino acid)platinum(II) complexes
Acridine-psoralen amines and their interaction with deoxyribonucleic acid
Spectroscopic Studies of Benzo(a)Pyrene-7,8-Dihydrodiol-9,10-Epoxides Covalently Bound to DNA
Linear dichroism study of 9-substituted acridines in stretched poly(vinyl alcohol) film
Structure of methylene blue–DNA complexes studied by linear and circular dichroism spectroscopy
Chromatin Structure Studied by Linear Dichroism at Different Salt Concentrations
Photo-Acoustic Linear Dichroism Spectroscopy. Polarized Light Spectroscopy of Biological Systems
Measurement of oriented circular dichroism
On the use of moments for describing the molecular orientation distribution
Simple formulas for dichroism analysis. Orientation of solutes in stretched polymer matrices
Determination of binding geometry of DNA-adduct systems through induced circular dichroism
Viscoelastic amphiphile aqueous solutions studied by linear dichroism spectroscopy
Structure of strand-separted DNA in different environments studied by linear dichroism
Simple formulas for rotation averages of spectroscopic intensities
Interaction Between DNA and 8-Methoxypsoralen Studied by Linear Dichroism
Electronic spectra of dithieno analogues of phenanthrene
Linear dichroism spectroscopy and its biological applications
Circular dichroism and the configuration of deprotonated tris-tartrato chromium(III) complex
Applications of linear Dichroism Spectroscopy
Form dichroism and the study of molecular shape
The magnetic circular dichroism of five-membered ring heterocycles
Structural evidence on DNA carcinogen interactions: N-acetoxy-N-2acetylaminofluorene binding to DNA
Renaturation of DNA in ethanol–methanol solvent induced by complexation with methyl green
Vortical flow as a source of optical activity in J aggregates of cyanine dyes
Linear Dichroism as a Tool for Characterizing Strand Separation in DNA
Binding of methyl green to deoxyribonucleic acid analyzed by linear dichroism
Long-Range Dispersion-Induced Circular Dichroism (DICD) of Electric Dipole Allowed Transitions
Absorption Statistics in Linear Dichroism
Linear dichroism probes to study internal electric fields
Magnetic circular dichroism of heterocycles: thiophene
Linear Dichroism of Chloroplasts and Subchloroplast Fractions Oriented by Flow
Linear dichroism spectroscopy as a tool for studying molecular orientation in model membrane systems
Electric Dichroism Spectroscopy
General Aspects on Linear Dichroism Spectroscopy and its Application
Permanent magnet interface for magnetic circular dichroism spectroscopy