I would say that I am interested in everything: to think about how life was created – and if it happened outside the Earth – to how an electron moves in an atom or how an electrical field surrounding an ion may catalyze a chemical reaction. Even though all my research projects are curiosity driven in the area of fundamental science, there are almost always also some interesting practical application associated. Studies of how molecules are ordered in liquid flow gave us for example a method to study protein and DNA structure in solution, an invention which we now daily apply in the laboratory. Another example, investigations how various substances can cross a lipid membrane may lead to new strategies for delivery of drugs into living cells and so on. The big grants received during 2008 (KAUST Award, Advanced Investigator ERC Grant and the Linné-center Bio-inspired Supramolecular Function and Design) have made it possible for me to start up projects that I earlier only had dreamt about. These projects encompass quite different kinds of problems but they are often approached with a common scientific approach: DNA is thus studied from both a biological point of view (e.g. new principles for recognition of long sequences, mechanisms for genetic recombination, gene therapy and transfection) as well as regarding how to use the DNA-base-pairing specificity and structural stability of the double helix to construct “addressable” two-dimensional networks for nano-technological applications (sensors, molecular electronics or nano-motors). Spectroscopy is another common basis of methodologies that we utilize to study structure and function for the molecular systems studied.
Visar 503 publikationer
Simultaneous binding of Ruthenium(II) [(1,10-phenanthroline)2(dipyridophenazine}]2+ and Minor Groove Binder 4,6-Diamidino-2-phenylindole to poly[d(A-T) 2] at high binding Densities: Observation of Fluorescence Resonance Energy Transfer Across the DNA Stem
Studies on the Adduct Heterogeneity of Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide Stereoisomers Covalently Bound to Deoxyribooligonucleotides by Induced Circular Dichroism and Light Absorption Spectroscopy
Induced Circular Dichroism of Benzo(a)pyrene-7,8-dihydrodiol 9,10-Epoxide Stereoisomers Covalently Bound to Deoxyribooligonucleotides Used to Probe Equilibrium Distribution between Groove Binding and Intercalative Adduct Conformations
SPECTROSCOPIC STUDIES OF THE TRANS ADDUCTS DERIVED FROM (+)-ANTI-BENZO A PYRENE-7,8-DIHYDRODIOL-9,10-EPOXIDE AND (-)-ANTI-BENZO A PYRENE-7,8-DIHYDRODIOL-9,10-EPOXIDE AND THE OLIGONUCLEOTIDE 5'-D(CCTATAGATATCC)
Spectroscopic studies on double-stranded poly d[(G-C)(G-C)] in B and Z form after covalent modification with the anti diastereomer of trans-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo,[a] pyrene
Structure of DNA metal complexes in solution studied by linear and circular dichroism. [Pt(II)(ethylenediamine)(2,2′-dipyridine)]2+ binds strongly to DNA by intercalation. [Cu(II)(2,2′-dipyridine)2]2+ is not intercalated