Ambivalent Intercalators for DNA: L-Shaped Platinum(II) Complexes
Artikel i vetenskaplig tidskrift, 2004

Novel platinum(II) square planar coordination complexes, in which two heteroaromatic ligands are held by the metal in an unusual L-shaped geometry orthogonal to each other, have been synthesized, and their interaction with DNA was investigated with absorption and linear dichroism spectroscopy. As a rule, the ligand that is coplanar with the coordination square of Pt is found to be oriented perpendicular relative to the DNA helix axis when bound, suggestive of its intercalation between the base pairs of DNA. However, when this coplanar ligand is replaced by two pyridines, the opposite ligand, orthogonal to the coordination square, is instead preferentially intercalated. This behavior shows that these new complexes do indeed show some properties of true ambintercalators, i.e., compounds that can bind by intercalation of either of two distinct aromatic moieties.

Författare

Bengt Nordén

Chalmers, Institutionen för kemi och biovetenskap, Fysikalisk kemi

Per Lincoln

Chalmers, Institutionen för kemi och biovetenskap, Fysikalisk kemi

Matteo Cusumano

Universita degli Studi di Messina

Maria Letizia Di Pietro

Universita degli Studi di Messina

Bengt Nordén

Chalmers University of Technology

Per Lincoln

Chalmers University of Technology

Inorganic Chemistry

0020-1669 (ISSN) 1520-510X (eISSN)

Vol. 43 2416-2421

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1021/ic035016f