Ambivalent Intercalators for DNA: L-Shaped Platinum(II) Complexes
Journal article, 2004

Novel platinum(II) square planar coordination complexes, in which two heteroaromatic ligands are held by the metal in an unusual L-shaped geometry orthogonal to each other, have been synthesized, and their interaction with DNA was investigated with absorption and linear dichroism spectroscopy. As a rule, the ligand that is coplanar with the coordination square of Pt is found to be oriented perpendicular relative to the DNA helix axis when bound, suggestive of its intercalation between the base pairs of DNA. However, when this coplanar ligand is replaced by two pyridines, the opposite ligand, orthogonal to the coordination square, is instead preferentially intercalated. This behavior shows that these new complexes do indeed show some properties of true ambintercalators, i.e., compounds that can bind by intercalation of either of two distinct aromatic moieties.

Author

Bengt Nordén

Chalmers, Department of Chemistry and Bioscience, Physical Chemistry

Per Lincoln

Chalmers, Department of Chemistry and Bioscience, Physical Chemistry

Matteo Cusumano

Universita degli Studi di Messina

Maria Letizia Di Pietro

Universita degli Studi di Messina

Bengt Nordén

Chalmers

Per Lincoln

Chalmers

Inorganic Chemistry

0020-1669 (ISSN) 1520-510X (eISSN)

Vol. 43 7 2416-2421

Subject Categories

Biochemistry and Molecular Biology

DOI

10.1021/ic035016f

More information

Latest update

9/10/2018