Per Lincolns research concerns nanoscale molecular recognition in a biochemical and biophysical context. The focus is to understand and develop mechanisms of selective interactions of small synthetic molecules with biomacromolecular assemblies such as DNA and lipid membranes, with the ultimate goal of finding new and more specific antibiotics.
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Simultaneous binding of Ruthenium(II) [(1,10-phenanthroline)2(dipyridophenazine}]2+ and Minor Groove Binder 4,6-Diamidino-2-phenylindole to poly[d(A-T) 2] at high binding Densities: Observation of Fluorescence Resonance Energy Transfer Across the DNA Stem
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