Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects
Journal article, 2017

X-ray crystal structures of three ?-[Ru(L)2dppz]2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2?-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5?-CG-3? step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5?-TA-3? sites. This result suggests that canted intercalation is preferred at 5?-CG-3? sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5?-CG-3? step could give rise to a longer luminescence lifetime than canted intercalation.

DNA structures

structural biology

nucleic acids

DNA

Author

James P. Hall

Diamond Light Source

University of Reading

Sarah P. Gurung

Diamond Light Source

University of Reading

Jessica Henle

University of Reading

Patrick Poidl

University of Reading

Johanna Andersson

Chalmers, Chemistry and Chemical Engineering, Applied Chemistry, Pharmaceutical Technology

Per Lincoln

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Graeme Winter

Diamond Light Source

Thomas Sorensen

Diamond Light Source

David J. Cardin

University of Reading

John A. Brazier

University of Reading

Christine J. Cardin

University of Reading

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 23 21 4981-4985

Driving Forces

Sustainable development

Areas of Advance

Nanoscience and Nanotechnology

Life Science Engineering

Subject Categories

Chemical Sciences

DOI

10.1002/chem.201605508

More information

Latest update

5/23/2018