Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects
Artikel i vetenskaplig tidskrift, 2017

X-ray crystal structures of three ?-[Ru(L)2dppz]2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2?-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5?-CG-3? step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5?-TA-3? sites. This result suggests that canted intercalation is preferred at 5?-CG-3? sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5?-CG-3? step could give rise to a longer luminescence lifetime than canted intercalation.

DNA structures

structural biology

nucleic acids

DNA

Författare

James P. Hall

Diamond Light Source

University of Reading

Sarah P. Gurung

Diamond Light Source

University of Reading

Jessica Henle

University of Reading

Patrick Poidl

University of Reading

Johanna Andersson

Chalmers, Kemi och kemiteknik, Tillämpad kemi, Farmaceutisk teknologi

Per Lincoln

Chalmers, Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Graeme Winter

Diamond Light Source

Thomas Sorensen

Diamond Light Source

David J. Cardin

University of Reading

John A. Brazier

University of Reading

Christine J. Cardin

University of Reading

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 23 21 4981-4985

Drivkrafter

Hållbar utveckling

Styrkeområden

Nanovetenskap och nanoteknik

Livsvetenskaper och teknik

Ämneskategorier

Kemi

DOI

10.1002/chem.201605508

Mer information

Senast uppdaterat

2018-05-23