Guanine Can Direct Binding Specificity of Ru–dipyridophenazine (dppz) Complexes to DNA through Steric Effects
Artikel i vetenskaplig tidskrift, 2017

X-ray crystal structures of three ?-[Ru(L)2dppz]2+ complexes (dppz=dipyridophenazine; L=1,10-phenanthroline (phen), 2,2?-bipyridine (bpy)) bound to d((5BrC)GGC/GCCG) showed the compounds intercalated at a 5?-CG-3? step. The compounds bind through canted intercalation, with the binding angle determined by the guanine NH2 group, in contrast to symmetrical intercalation previously observed at 5?-TA-3? sites. This result suggests that canted intercalation is preferred at 5?-CG-3? sites even though the site itself is symmetrical, and we hypothesise that symmetrical intercalation in a 5?-CG-3? step could give rise to a longer luminescence lifetime than canted intercalation.

nucleic acids


structural biology

DNA structures


James P. Hall

University of Reading

Diamond Light Source

Sarah P. Gurung

Diamond Light Source

University of Reading

Jessica Henle

University of Reading

Patrick Poidl

University of Reading

Johanna Andersson

Kemi och kemiteknik, Tillämpad kemi, Farmaceutisk teknologi

Per Lincoln

Kemi och kemiteknik, Kemi och biokemi, Fysikalisk kemi

Graeme Winter

Diamond Light Source

Thomas Sorensen

Diamond Light Source

David J. Cardin

University of Reading

John A. Brazier

University of Reading

Christine J. Cardin

University of Reading

Chemistry - A European Journal

0947-6539 (ISSN) 1521-3765 (eISSN)

Vol. 23 4981-4985


Hållbar utveckling


Nanovetenskap och nanoteknik

Livsvetenskaper och teknik