Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes
Journal article, 2014
The crystal structure of the ,enantiomer of the binuclear light-switch ruthenium complex [-(11,11-bidppz)(1,10-phenanthroline)(4)Ru-2](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.
quadruplex
intercalation
recognition
metal-complexes
crystal-structure
small-molecule
binuclear ruthenium complexes
junction
promoter
binding
Author
D. Roeland Boer
IRB Barcelona - Institute for Research in Biomedicine
Lisha Wu
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Miquel Coll
CSIC - Instituto de Biologia Molecular de Barcelona (IBMB)
IRB Barcelona - Institute for Research in Biomedicine
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 53 7 1949-1952Subject Categories
Chemical Sciences
DOI
10.1002/anie.201308070