Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes
Journal article, 2014
The crystal structure of the ,enantiomer of the binuclear light-switch ruthenium complex [-(11,11-bidppz)(1,10-phenanthroline)(4)Ru-2](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.
binding
recognition
quadruplex
promoter
crystal-structure
binuclear ruthenium complexes
junction
metal-complexes
small-molecule
intercalation
Author
D. Roeland Boer
IRB Barcelona - Institute for Research in Biomedicine
Lisha Wu
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Per Lincoln
Chalmers, Chemical and Biological Engineering, Physical Chemistry
Miquel Coll
Spanish National Research Council (CSIC)
IRB Barcelona - Institute for Research in Biomedicine
Published in
Angewandte Chemie - International Edition
1433-7851 (ISSN) 1521-3773 (eISSN)
Vol. 53 Issue 7 p. 1949-1952Categorizing
Subject Categories (SSIF 2011)
Chemical Sciences
Identifiers
DOI
10.1002/anie.201308070