Thread Insertion of a Bis(dipyridophenazine) Diruthenium Complex into the DNA Double Helix by the Extrusion of AT Base Pairs and Cross-Linking of DNA Duplexes
Artikel i vetenskaplig tidskrift, 2014

The crystal structure of the ,enantiomer of the binuclear light-switch ruthenium complex [-(11,11-bidppz)(1,10-phenanthroline)(4)Ru-2](4+) bound to the oligonucleotide d(CGTACG) shows that one dppz moiety of the dumbbell-like compound inserts into the DNA stack through the extrusion of an AT base pair. The second dppz moiety recruits a neighboring DNA molecule, and the complex thus cross-links two adjacent duplexes by bridging their major grooves.

quadruplex

intercalation

recognition

metal-complexes

crystal-structure

small-molecule

binuclear ruthenium complexes

junction

promoter

binding

Författare

D. Roeland Boer

IRB Barcelona - Institute for Research in Biomedicine

Lisha Wu

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Miquel Coll

CSIC - Instituto de Biologia Molecular de Barcelona (IBMB)

IRB Barcelona - Institute for Research in Biomedicine

Angewandte Chemie - International Edition

1433-7851 (ISSN) 1521-3773 (eISSN)

Vol. 53 1949-1952

Ämneskategorier

Kemi

DOI

10.1002/anie.201308070