Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates
Journal article, 2009

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

supramolecular cylinder





linear dichroism spectroscopy




Y. Parajo


J. Malina

The University of Warwick

I. Meistermann

The University of Warwick

G. J. Clarkson

The University of Warwick

M. Pascu

University of Birmingham

The University of Warwick

A. Rodger

The University of Warwick

M. J. Hannon

The University of Warwick

University of Birmingham

Per Lincoln

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Dalton Transactions

1477-9226 (ISSN) 1477-9234 (eISSN)

25 4868-4874

Subject Categories

Physical Chemistry

Chemical Sciences



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