Effect of bridging ligand structure on the thermal stability and DNA binding properties of iron(II) triple helicates
Artikel i vetenskaplig tidskrift, 2009

Triple helical di-iron complexes, readily prepared through interaction of iron(II) ions with imine-based ligands, are cylinder-shaped tetracations comparable in size and shape to common protein DNA recognition units. They have a strong tendency to coil DNA, and have recently been found to induce formation of three-way junctions in palindromic oligonucleotides. To introduce potential H bond acceptor units onto the surface of triple-helicates, new iron(II) complexes have been synthesized in which the central linking unit in the bridging ligand is S or O, instead of CH2. The DNA binding properties of these new metallo-helicates were studied using UV-vis spectroscopy and circular and linear dichroism. Results show that the three iron triple helicates bind the DNA in a similar way but that the stability of the triple helicate unit is decreased with the O linked bridging ligand.

complexes

junction

linear dichroism spectroscopy

recognition

nucleic-acids

nmr

molecular

supramolecular cylinder

Författare

Y. Parajo

Chalmers University of Technology

J. Malina

The University of Warwick

I. Meistermann

The University of Warwick

G. J. Clarkson

The University of Warwick

M. Pascu

The University of Warwick

University of Birmingham

A. Rodger

The University of Warwick

M. J. Hannon

The University of Warwick

University of Birmingham

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Dalton Transactions

1477-9226 (ISSN) 1477-9234 (eISSN)

4868-4874

Ämneskategorier

Fysikalisk kemi

Kemi

DOI

10.1039/b822039e