Binuclear ruthenium(II) phenanthroline compounds with extreme binding affinity for DNA

Journal article, 1996

Dimeric homochiral ruthenium complexes [L(2)Ru{dppz(11-11')dppz}RuL(2)](4+) (L = 1,10-phenanthroline, 2,2'-bipyridyl; dppz = dipyrido[3,2-A:2',3'-C]phenazine) bind extremely strongly to duplex DNA with different binding geometries for the Delta Delta and Lambda Lambda enantiomers of the phenanthroline complex but with similar geometries for the bipyridyl complex enantiomers.