Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity
Journal article, 2019

We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)2b4bpy]2+, Δ-4Ru) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the AATT sequence, while the other enantiomer preferentially targets long AAATTT sites with overall lower affinity. Finally, we demonstrate that the photophysical properties of these new binders can be exploited for DNA cleavage using visible light.

Author

Mateo I. Sánchez

Universidade de Santiagode Compostela

Gustavo Rama

Universidade de Santiagode Compostela

Renata Calo-Lapido

Universidade de Santiagode Compostela

Kubra Ucar

Chalmers, Chemistry and Chemical Engineering, Chemistry and Biochemistry, Physical Chemistry

Per Lincoln

Chalmers, Chemistry and Chemical Engineering

Miguel Vázquez López

Universidade de Santiagode Compostela

Manuel Melle-Franco

University of Aveiro

José L. Mascarenãs

Universidade de Santiagode Compostela

M. Eugenio Vázquez

Universidade de Santiagode Compostela

Chemical Science

2041-6520 (ISSN) 2041-6539 (eISSN)

Vol. 10 37 8668-8674

Subject Categories

Biochemistry and Molecular Biology

Biophysics

Other Industrial Biotechnology

DOI

10.1039/c9sc03053k

More information

Latest update

11/4/2019