Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran
Journal article, 2010

A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.

light-activation

DNA recognition

DNA-binding

photochromism

molecular logic

Author

Martin Hammarson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Johanna Andersson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Shiming Li

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Per Lincoln

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Joakim Andreasson

Chalmers, Chemical and Biological Engineering, Physical Chemistry

Chemical Communications

1359-7345 (ISSN)

Vol. 46 38 7130-7132

Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs (PHOTOCHROMES)

European Commission (FP7), 2008-09-01 -- 2013-08-31.

Subject Categories

Physical Chemistry

DOI

10.1039/c0cc01682a

More information

Created

10/7/2017