Molecular AND-logic for dually controlled activation of a DNA-binding spiropyran
Artikel i vetenskaplig tidskrift, 2010
A spiropyran photoswitch is activated using UV light and protons from a form that shows no interaction with DNA to a form that binds to DNA by intercalation. This scheme is interpreted as a biologically relevant logic AND gate with potential applications as a dually controlled anticancer drug.
light-activation
DNA recognition
DNA-binding
photochromism
molecular logic
Författare
Martin Hammarson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Johanna Andersson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Shiming Li
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Per Lincoln
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Joakim Andreasson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Chemical Communications
1359-7345 (ISSN)
Vol. 46 38 7130-7132Photochromic Systems for Solid State Molecular Electronic Devices and Light-Activated Cancer Drugs (PHOTOCHROMES)
Europeiska kommissionen (FP7), 2008-09-01 -- 2013-08-31.
Ämneskategorier
Fysikalisk kemi
DOI
10.1039/c0cc01682a