Sequential One-Pot Ruthenium-Catalyzed Azide-Alkyne Cycloaddition from Primary Alkyl Halides and Sodium Azide
Artikel i vetenskaplig tidskrift, 2011

An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from; an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*-(PPh3)(2)] and the alkyne yielded the desired cycloaddition product after further microwave irradiation.

click chemistry

amines

diversity

2

4-disubstituted 1

analogs

terminal alkynes

scope

organic azides

1

triazole linkages

3-triazoles

Författare

Johan Johansson

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Per Lincoln

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Bengt Nordén

Chalmers, Kemi- och bioteknik, Fysikalisk kemi

Nina Kann

Chalmers, Kemi- och bioteknik, Organisk kemi

Journal of Organic Chemistry

0022-3263 (ISSN) 1520-6904 (eISSN)

Vol. 76 2355-2359

Styrkeområden

Energi

Materialvetenskap

Ämneskategorier

Organisk kemi

DOI

10.1021/jo200134a