Sequential One-Pot Ruthenium-Catalyzed Azide-Alkyne Cycloaddition from Primary Alkyl Halides and Sodium Azide
Artikel i vetenskaplig tidskrift, 2011
An experimentally simple sequential one-pot RuAAC reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields starting from; an alkyl halide, sodium azide, and an alkyne, is reported. The organic azide is formed in situ by treating the primary alkyl halide with sodium azide in DMA under microwave heating. Subsequent addition of [RuClCp*-(PPh3)(2)] and the alkyne yielded the desired cycloaddition product after further microwave irradiation.
click chemistry
amines
diversity
2
4-disubstituted 1
analogs
terminal alkynes
scope
organic azides
1
triazole linkages
3-triazoles
Författare
Johan Johansson
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Per Lincoln
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Bengt Nordén
Chalmers, Kemi- och bioteknik, Fysikalisk kemi
Nina Kann
Chalmers, Kemi- och bioteknik, Organisk kemi
Journal of Organic Chemistry
0022-3263 (ISSN) 1520-6904 (eISSN)
Vol. 76 7 2355-2359Styrkeområden
Energi
Materialvetenskap
Ämneskategorier
Organisk kemi
DOI
10.1021/jo200134a