THE CD OF LIGAND-DNA SYSTEMS .1. POLY(DG-DC) B-DNA
Artikel i vetenskaplig tidskrift, 1991
A systematic theoretical study of the CD of double-stranded poly (dG-dC) and its complexes with small molecules is presented. The intrinsic CD of the polymer and the induced CD of a transition belonging to a molecule bound to DNA are calculated using the matrix method. The calculations show considerable differences between pyrimidine-purine and purine-pyrimidine binding sites, and we find that the induced CD of a groove bound molecule is one order of magnitude stronger than that of an intercalated molecule. The results form a sound basis for interpreting the CD of ligand-DNA systems in terms of molecular geometry, interactions, and spectroscopy.
perturbation
drug-binding
nucleic-acids
complexes
model
induced circular-dichroism
fluorescence
dipole allowed transitions
polynucleotides
dapi
Författare
Reidar Lyng
Institutionen för fysikalisk kemi
A. Rodger
Bengt Nordén
Institutionen för fysikalisk kemi
Biopolymers
0006-3525 (ISSN) 1097-0282 (eISSN)
Vol. 31 14 1709-1720Ämneskategorier
Biokemi och molekylärbiologi
DOI
10.1002/bip.360311405