THE CD OF LIGAND-DNA SYSTEMS .1. POLY(DG-DC) B-DNA
Artikel i vetenskaplig tidskrift, 1991

A systematic theoretical study of the CD of double-stranded poly (dG-dC) and its complexes with small molecules is presented. The intrinsic CD of the polymer and the induced CD of a transition belonging to a molecule bound to DNA are calculated using the matrix method. The calculations show considerable differences between pyrimidine-purine and purine-pyrimidine binding sites, and we find that the induced CD of a groove bound molecule is one order of magnitude stronger than that of an intercalated molecule. The results form a sound basis for interpreting the CD of ligand-DNA systems in terms of molecular geometry, interactions, and spectroscopy.

perturbation

drug-binding

nucleic-acids

complexes

model

induced circular-dichroism

fluorescence

dipole allowed transitions

polynucleotides

dapi

Författare

Reidar Lyng

Institutionen för fysikalisk kemi

A. Rodger

Bengt Nordén

Institutionen för fysikalisk kemi

Biopolymers

0006-3525 (ISSN) 1097-0282 (eISSN)

Vol. 31 14 1709-1720

Ämneskategorier

Biokemi och molekylärbiologi

DOI

10.1002/bip.360311405