Binding geometry of benzo[a] pyrene diol epoxide covalently bound to DNA. A flow linear dichroism study
Artikel i vetenskaplig tidskrift, 1986

Flow linear dichroism (LD) provides new structural information on 7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene (anti-BPDE) covalently bound to DNA: by resolving the LD spectrum with respect to the polarized absorption components of the pyrenyl chromophore, we have determined the orientations of the in-plane symmetry axes of the bound compound relative to the helix axis of DNA [they are on average oriented at 70°(short axis) and 30°(long axis)]; for both (+)- and (–)-anti-BPDE adducts the flexibility of the DNA is increased.

Författare

Magdalena Eriksson

Institutionen för fysikalisk kemi

B. Jernstrom

A. Graslund

Bengt Nordén

Institutionen för fysikalisk kemi

Journal of the Chemical Society - Series Chemical Communications

0022-4936 (ISSN)

1613-1615

Ämneskategorier

Kemi

DOI

10.1039/c39860001613