Binding geometry of benzo[a] pyrene diol epoxide covalently bound to DNA. A flow linear dichroism study
Journal article, 1986

Flow linear dichroism (LD) provides new structural information on 7β,8α-dihydroxy-9α, 10α-epoxy-7,8,9,10-tetrahydrobenzo[a] pyrene (anti-BPDE) covalently bound to DNA: by resolving the LD spectrum with respect to the polarized absorption components of the pyrenyl chromophore, we have determined the orientations of the in-plane symmetry axes of the bound compound relative to the helix axis of DNA [they are on average oriented at 70°(short axis) and 30°(long axis)]; for both (+)- and (–)-anti-BPDE adducts the flexibility of the DNA is increased.

Author

Magdalena Eriksson

Department of Physical Chemistry

B. Jernstrom

A. Graslund

Bengt Nordén

Department of Physical Chemistry

Journal of the Chemical Society - Series Chemical Communications

0022-4936 (ISSN)

21 1613-1615

Subject Categories

Chemical Sciences

DOI

10.1039/c39860001613

More information

Created

10/7/2017