EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS
Artikel i vetenskaplig tidskrift, 1993
The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied. (C) 1993 Wiley-Liss, Inc.
potassium ion
low-frequency
behavior
electric-fields
binding
cyclotron-resonance
brain-tissue invitro
gramicidin-a
radiation
cyclotron resonance
gramicidin
efflux
elf
bilayer membrane
Författare
Sheila Galt
Institutionen för mikrovågsteknik
J. Sandblom
Yngve Hamnerius
Institutionen för mikrovågsteknik
P. Hojevik
Elisabeth Saalman
Bengt Nordén
Institutionen för fysikalisk kemi
Bioelectromagnetics
0197-8462 (ISSN) 1521-186X (eISSN)
Vol. 14 4 315-327Ämneskategorier
Fysikalisk kemi
Biologiska vetenskaper
DOI
10.1002/bem.2250140404