EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS
Artikel i vetenskaplig tidskrift, 1993

The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied. (C) 1993 Wiley-Liss, Inc.

potassium ion

low-frequency

behavior

electric-fields

binding

cyclotron-resonance

brain-tissue invitro

gramicidin-a

radiation

cyclotron resonance

gramicidin

efflux

elf

bilayer membrane

Författare

Sheila Galt

Institutionen för mikrovågsteknik

J. Sandblom

Yngve Hamnerius

Institutionen för mikrovågsteknik

P. Hojevik

Elisabeth Saalman

Bengt Nordén

Institutionen för fysikalisk kemi

Bioelectromagnetics

0197-8462 (ISSN) 1521-186X (eISSN)

Vol. 14 4 315-327

Ämneskategorier

Fysikalisk kemi

Biologiska vetenskaper

DOI

10.1002/bem.2250140404